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dc.contributor.authorBrouwer, Niels J
dc.contributor.authorMarinkovic, Marina
dc.contributor.authorBleeker, Jaco C
dc.contributor.authorEl Filali, Mariam
dc.contributor.authorStefansson, Einar
dc.contributor.authorLuyten, Gregorius P M
dc.contributor.authorJager, Martine J
dc.date.accessioned2020-12-16T13:58:50Z
dc.date.available2020-12-16T13:58:50Z
dc.date.issued2020-11
dc.date.submitted2020-11
dc.identifier.citationBrouwer NJ, Marinkovic M, Bleeker JC, El Filali M, Stefansson E, Luyten GPM, Jager MJ. RETINAL OXIMETRY IS ALTERED IN EYES WITH CHOROIDAL MELANOMA BUT NOT IN EYES WITH CHOROIDAL NEVI. Retina. 2020 Nov;40(11):2207-2215. doi: 10.1097/IAE.0000000000002719.en_US
dc.identifier.pmid31851050
dc.identifier.doi10.1097/IAE.0000000000002719
dc.identifier.urihttp://hdl.handle.net/2336/621609
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractPurpose: To compare retinal vessel oxygenation in eyes with an untreated choroidal nevus or choroidal melanoma. Methods: The affected and fellow eye of patients with an untreated choroidal nevus (n = 42) or choroidal melanoma (n = 45) were investigated using noninvasive retinal oximetry (Oxymap T1). Oxygen saturation of arterioles (ArtSat) and venules (VenSat) was determined, together with the arteriovenous difference (AV-difference). Results: In choroidal nevus patients, retinal oximetry did not differ between the affected and fellow eye: the mean ArtSat was 94.5% and 94.2% (P = 0.56), the VenSat was 60.5% and 61.3% (P = 0.35), and the AV-difference was 34.0% and 32.9% (P = 0.18), respectively. In choroidal melanoma patients, alterations were detected: the mean ArtSat was 94.8% and 93.2% (P = 0.006), the VenSat was 58.0% and 60.0% (P = 0.014), and the AV-difference was 36.8% and 33.2% (P < 0.001), respectively. The largest increase in AV-difference was observed between the retinal halves without the lesion in melanoma eyes compared with the corresponding half in the fellow eye (37.5% vs. 32.1%, P < 0.001). Conclusion: Although retinal oximetry was not significantly altered in eyes with a choroidal nevus, eyes with choroidal melanoma showed an increased ArtSat and decreased VenSat, leading to an increased AV-difference. These changes may be caused by inflammation and a higher metabolism, with larger oxygen consumption, leading to altered blood flow and intraocular oxygen relocation.en_US
dc.description.sponsorshipLeiden University Medical Center Stichting Nederlands Oogheelkundig Onderzoek (SNOO)en_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.urlhttps://journals.lww.com/retinajournal/pages/articleviewer.aspx?year=2020&issue=11000&article=00020&type=Fulltexten_US
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575014/en_US
dc.subjectAugnsjúkdómaren_US
dc.subject.meshChoroid Neoplasmsen_US
dc.subject.meshOximetryen_US
dc.titleRETINAL OXIMETRY IS ALTERED IN EYES WITH CHOROIDAL MELANOMA BUT NOT IN EYES WITH CHOROIDAL NEVI.en_US
dc.typeArticleen_US
dc.identifier.eissn1539-2864
dc.contributor.department1Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands. 2Department of Ophthalmology, Reinier de Graaf Gasthuis, Delft, The Netherlands. 3Department of Ophthalmology, Landspitali University Hospital, University of Iceland, Reykjavik, Iceland.en_US
dc.identifier.journalRetina (Philadelphia, Pa.)en_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.departmentcodeOPH12
dc.source.journaltitleRetina (Philadelphia, Pa.)
dc.source.volume40
dc.source.issue11
dc.source.beginpage2207
dc.source.endpage2215
dc.source.countryUnited States


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