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dc.contributor.authorDesmirean, Minodora
dc.contributor.authorRauch, Sebastian
dc.contributor.authorJurj, Ancuta
dc.contributor.authorPasca, Sergiu
dc.contributor.authorIluta, Sabina
dc.contributor.authorTeodorescu, Patric
dc.contributor.authorBerce, Cristian
dc.contributor.authorZimta, Alina-Andreea
dc.contributor.authorTurcas, Cristina
dc.contributor.authorTigu, Adrian-Bogdan
dc.contributor.authorMoldovan, Cristian
dc.contributor.authorParis, Irene
dc.contributor.authorSteinheber, Jakob
dc.contributor.authorRichlitzki, Cedric
dc.contributor.authorConstantinescu, Catalin
dc.contributor.authorSigurjonsson, Olafur Eysteinn
dc.contributor.authorDima, Delia
dc.contributor.authorPetrushev, Bobe
dc.contributor.authorTomuleasa, Ciprian
dc.date.accessioned2021-01-08T10:11:39Z
dc.date.available2021-01-08T10:11:39Z
dc.date.issued2020-10-24
dc.date.submitted2021-01
dc.identifier.citationDesmirean M, Rauch S, Jurj A, Pasca S, Iluta S, Teodorescu P, et al. B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974? Journal of clinical medicine. 2020;9(11).doi:10.3390/jcm9113412.en_US
dc.identifier.issn2077-0383
dc.identifier.pmid33114418
dc.identifier.doi10.3390/jcm9113412
dc.identifier.urihttp://hdl.handle.net/2336/621621
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Downloaden_US
dc.description.abstractMalignant lymphomas are a heterogeneous group of malignancies that develop both in nodal and extranodal sites. The different tissues involved and the highly variable clinicopathological characteristics are linked to the association between the lymphoid neoplastic cells and the tissues they infiltrate. The immune system has developed mechanisms to protect the normal tissue from malignant growth. In this review, we aim to explain how T lymphocyte-driven control is linked to tumor development and describe the tumor-suppressive components of the resistant framework. This manuscript brings forward a new insight with regard to intercellular and intracellular signaling, the immune microenvironment, the impact of therapy, and its predictive implications. A better understanding of the key components of the lymphoma environment is important to properly assess the role of both B and T lymphocytes, as well as their interplay, just as two legendary boxers face each other in a heavyweight title final, as was the case of Ali versus Foreman. Keywords: B lymphocytes; T lymphocytes; lymphocyte inter-talk; malignant lymphomas; tumor microenvironment.en_US
dc.description.sponsorshipIuliu Hatieganu University, School of Doctoral Studies RomanianMinistry of Research and Innovation, CCCDI-UEFISCDI within PNCDI III European Economic Spaceen_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.urlhttps://www.mdpi.com/2077-0383/9/11/3412en_US
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693982/
dc.subjectB lymphocytesen_US
dc.subjectT lymphocytesen_US
dc.subjectlymphocyte inter-talken_US
dc.subjectmalignant lymphomasen_US
dc.subjecttumor microenvironmenten_US
dc.subject.meshLymphomaen_US
dc.titleB Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974?en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.contributor.department1Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 400124 Cluj Napoca, Romania. 2Department of Pathology, Constantin Papilian Military Hospital, 400124 Cluj Napoca, Romania. 3Medfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400124 Cluj Napoca, Romania. 4Department of Anesthesia and Intensive Care, Iuliu Hatieganu University of Medicine and Pharmacy, 400124 Cluj Napoca, Romania. 5The Blood Bank, Landspitali-The National University Hospital of Iceland, 101 Reykjavik, Iceland. 6School of Science and Engineering, Reykjavik University, 101 Reykjavik, Iceland. 7Department of Hematology, Ion Chiricuta Clinical Cancer Center, 400124 Cluj Napoca, Romania. 8Department of Pathology, Octavian Fodor Regional Institute of Gastroenterology and Hepatology, 400124 Cluj Napoca, Romania.en_US
dc.identifier.journalJournal of clinical medicineen_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.departmentcodeNAF12
dc.source.journaltitleJournal of clinical medicine
dc.source.volume9
dc.source.issue11
refterms.dateFOA2021-01-08T10:11:40Z
dc.source.countrySwitzerland


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