Show simple item record

dc.contributor.authorWeisner, Gwen
dc.contributor.authorBlindbaek, Søren Leer
dc.contributor.authorTang, Fang Yao
dc.contributor.authorCheung, Carol Y
dc.contributor.authorHenriksen, Jan Erik
dc.contributor.authorStefánsson, Einar
dc.contributor.authorPeto, Tunde
dc.contributor.authorGrauslund, Jakob
dc.date.accessioned2021-02-22T15:40:50Z
dc.date.available2021-02-22T15:40:50Z
dc.date.issued2021-01-08
dc.date.submitted2021-02
dc.identifier.citationWeisner G, Blindbaek SL, Tang FY, Cheung CY, Henriksen JE, Stefánsson E, et al. Non-invasive structural and metabolic retinal markers of disease activity in non-proliferative diabetic retinopathy. Acta ophthalmologica. 2021.doi:10.1111/aos.14761.en_US
dc.identifier.pmid33416216
dc.identifier.doi10.1111/aos.14761
dc.identifier.urihttp://hdl.handle.net/2336/621671
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractPurpose: Metabolic and structural microvascular retinal alterations are essential components in diabetic retinopathy (DR). The present study aimed to measure changes at different stages of non-proliferative DR (NPDR) and to explore interactions of imaging-based metrics. Methods: This cross-sectional, cohort study included 139 eyes from 80 diabetic patients. Each patient underwent dilated fundal examinations including colour fundus photography, retinal oximetry and optical coherence tomography angiography (OCTA), analysed by semi-automated and automated software. Diabetic retinopathy (DR) severity was classified according to the International Clinical Diabetic Retinopathy (ICDR) Severity Scale, ranging from no DR to severe NPDR (level 0-3). Retinal metabolism was evaluated by oximetry as retinal arteriolar (raSatO2 ) and venular oxygen saturation (rvSatO2 ), and macular microvascular structure was measured by OCTA as the area of foveal avascular zone (FAZ), vessel density (VD), vessel diameter index (VDI), FAZ circularity and fractal dimension (FD) in the superficial and deep retinal capillary plexus. Results: A trend for increasing rvSatO2 was found with increasing DR severity (51.3%, 53.3%, 54.2%, 59.8%, p = 0.02). Increasing severity of DR associated with decreasing FD in the superficial and deep plexus (p < 0.001 and p = 0.014), and in the superficial plexus decreasing VD (p < 0.001), increasing VDI (p = 0.003) and decreasing FAZ circularity (p = 0.006). A few interactions were identified between raSatO2 , rvSatO2 and VDI, but only in the deep capillary plexus (p < 0.01 and p < 0.01). Conclusion: Alterations of the venular retinal vascular oxygen saturation and microvascular structural abnormities were found continuously throughout the DR-spectrum. Given the sparse correlations between metabolic and structural abnormalities, it seems that these occur independently in DR. Keywords: diabetes; diabetic retinopathy; non-proliferative diabetic retinopathy; optical coherence tomography angiography; retinal oximetry.en_US
dc.description.sponsorshipOdense University Hospital University of Southern Denmark A. P. Moller Foundation for the Advancement of Medical Science OPEN, Open Patient data Explorative Network, Odense University Hospital, Odense, Denmark Belfast Reading Centre Royal Victoria Hospitalen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1111/aos.14761en_US
dc.rights© 2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
dc.subjectdiabetesen_US
dc.subjectdiabetic retinopathyen_US
dc.subjectnon-proliferative diabetic retinopathyen_US
dc.subjectoptical coherence tomography angiographyen_US
dc.subjectretinal oximetryen_US
dc.subjectsykursýkissjónukvillien_US
dc.subjectSykursýkien_US
dc.subjectAugnsjúkdómaren_US
dc.titleNon-invasive structural and metabolic retinal markers of disease activity in non-proliferative diabetic retinopathy.en_US
dc.typeArticleen_US
dc.identifier.eissn1755-3768
dc.contributor.department1Department of Ophthalmology, Odense University Hospital, Odense, Denmark. 2Department of Clinical Research, University of Southern Denmark, Odense, Denmark. 3Centre for Public Health, Queen's University Belfast, Belfast, UK. 4OPEN, Open Patient data Explorative Network, Odense University Hospital, Odense, Denmark. 5Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. 6Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. 7University of Iceland, Reykjavik, Iceland. 8Landspitali University Hospital, Reykjavik, Iceland.en_US
dc.identifier.journalActa ophthalmologicaen_US
dc.rights.accessNational Consortium - Landsaðganguren_US
dc.departmentcodeOPH12
dc.source.journaltitleActa ophthalmologica
dc.source.countryEngland


This item appears in the following Collection(s)

Show simple item record