Cumulative Occupational Exposures and Lung-Function Decline in Two Large General-Population Cohorts.
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Authors
Lytras, TheodoreBeckmeyer-Borowko, Anna
Kogevinas, Manolis
Kromhout, Hans
Carsin, Anne-Elie
Antó, Josep Maria
Bentouhami, Hayat
Weyler, Joost
Heinrich, Joachim
Nowak, Dennis
Urrutia, Isabel
Martínez-Moratalla, Jesús
Gullón, José Antonio
Pereira Vega, Antonio
Raherison Semjen, Chantal
Pin, Isabelle
Demoly, Pascal
Leynaert, Bénédicte
Villani, Simona
Gislason, Thorarinn
Svanes, Øistein
Holm, Mathias
Forsberg, Bertil
Norbäck, Dan
Mehta, Amar J
Keidel, Dirk
Vernez, David
Benke, Geza
Jõgi, Rain
Torén, Kjell
Sigsgaard, Torben
Schlünssen, Vivi
Olivieri, Mario
Blanc, Paul D
Watkins, John
Bono, Roberto
Squillacioti, Giulia
Buist, A Sonia
Vermeulen, Roel
Jarvis, Deborah
Probst-Hensch, Nicole
Zock, Jan-Paul
Issue Date
2021-02
Metadata
Show full item recordCitation
Lytras T, Beckmeyer-Borowko A, Kogevinas M, Kromhout H, Carsin AE, Antó JM, et al. Cumulative Occupational Exposures and Lung-Function Decline in Two Large General-Population Cohorts. Annals of the American Thoracic Society. 2021;18(2):238-46.doi:10.1513/AnnalsATS.202002-113OC.Abstract
Rationale: Few longitudinal studies have assessed the relationship between occupational exposures and lung-function decline in the general population with a sufficiently long follow-up.Objectives: To examine the potential association in two large cohorts: the ECRHS (European Community Respiratory Health Survey) and the SAPALDIA (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults).Methods: General-population samples of individuals aged 18 to 62 were randomly selected in 1991-1993 and followed up approximately 10 and 20 years later. Spirometry (without bronchodilation) was performed at each visit. Coded complete job histories during follow-up visits were linked to a job-exposure matrix, generating cumulative exposure estimates for 12 occupational exposures. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were jointly modeled in linear mixed-effects models, fitted in a Bayesian framework, taking into account age and smoking.Results: A total of 40,024 lung-function measurements from 17,833 study participants were analyzed. We found accelerated declines in FEV1 and the FEV1/FVC ratio for exposure to biological dust, mineral dust, and metals (FEV1 = -15.1 ml, -14.4 ml, and -18.7 ml, respectively; and FEV1/FVC ratio = -0.52%, -0.43%, and -0.36%, respectively; per 25 intensity-years of exposure). These declines were comparable in magnitude with those associated with long-term smoking. No effect modification by sex or smoking status was identified. Findings were similar between the ECRHS and the SAPALDIA cohorts.Conclusions: Our results greatly strengthen the evidence base implicating occupation, independent of smoking, as a risk factor for lung-function decline. This highlights the need to prevent or control these exposures in the workplace.Description
To access publisher's full text version of this article click on the hyperlink belowAdditional Links
https://www.atsjournals.org/doi/10.1513/AnnalsATS.202002-113OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedae974a485f413a2113503eed53cd6c53
10.1513/AnnalsATS.202002-113OC
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