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dc.contributor.authorVidarsdottir, Harpa
dc.contributor.authorHalldorsson, Thorhallur Ingi
dc.contributor.authorGeirsson, Reynir Tomas
dc.contributor.authorBjarnason, Ragnar
dc.contributor.authorFranzson, Leifur
dc.contributor.authorValdimarsdottir, Unnur Anna
dc.contributor.authorThorkelsson, Thordur
dc.date.accessioned2021-04-27T13:53:09Z
dc.date.available2021-04-27T13:53:09Z
dc.date.issued2021-02-26
dc.date.submitted2021-04
dc.identifier.citationVidarsdottir H, Halldorsson TI, Geirsson RT, Bjarnason R, Franzson L, Valdimarsdottir UA, Thorkelsson T. Mode of delivery was associated with transient changes in the metabolomic profile of neonates. Acta Paediatr. 2021 Feb 26. doi: 10.1111/apa.15822.en_US
dc.identifier.pmid33636029
dc.identifier.doi10.1111/apa.15822
dc.identifier.urihttp://hdl.handle.net/2336/621765
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractAims: To estimate potential differences in neonatal metabolomic profiles at birth and at the time of newborn screening by delivery mode. Methods: A prospective study at Women's Clinic at Landspitali-The National University Hospital of Iceland. Women having normal vaginal birth or elective caesarean section from November 2013 to April 2014 were offered participation. Blood samples from mothers before birth and umbilical cord at birth were collected and amino acids and acylcarnitines measured by tandem mass spectrometry. Results from the Newborn screening programme in Iceland were collected. Amino acids and acylcarnitines from different samples were compared by delivery mode. Results: Eighty three normal vaginal births and 32 elective caesarean sections were included. Mean differences at birth were higher for numerous amino acids, and some acylcarnitines in neonates born vaginally compared to elective caesarean section. Maternal blood samples and newborn screening results showed small differences that lost significance after correction for multiple testing. Many amino acids and some acylcarnitines were numerically higher in cord blood compared to maternal. Many amino acids and most acylcarnitines were numerically higher in newborn screening results compared to cord blood. Conclusion: We observed transient yet distinct differences in metabolomic profiles between neonates by delivery mode. Keywords: acylcarnitines; amino acids; delivery mode; metabolomic profile; newborn screening.en_US
dc.description.sponsorshipUniversity of Iceland Research Funden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1111/apa.15822en_US
dc.rights© 2021 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
dc.subjectacylcarnitinesen_US
dc.subjectamino acidsen_US
dc.subjectdelivery modeen_US
dc.subjectmetabolomic profileen_US
dc.subjectnewborn screeningen_US
dc.subjectFæðingen_US
dc.subjectUngbörnen_US
dc.subjectEfnaskiptien_US
dc.subject.meshDelivery, Obstetricen_US
dc.subject.meshNeonatal Screeningen_US
dc.subject.meshMetabolismen_US
dc.titleMode of delivery was associated with transient changes in the metabolomic profile of neonates.en_US
dc.typeArticleen_US
dc.identifier.eissn1651-2227
dc.contributor.department1Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 2Department of Neonatology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. 3Faculty for Food Science and Nutrition, School of Health Science, University of Iceland, Reykjavik, Iceland. 4Women's Clinic, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 5Children's Hospital Iceland, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 6Faculty of Pharmaceutical Sciences, School of Health Science, University of Iceland, Reykjavik, Iceland. 7Department of Genetics and Molecular Medicine, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 8Center for Public Health Science, School of Health Science, University of Iceland, Reykjavik, Iceland. 9Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 10Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA.en_US
dc.identifier.journalActa paediatrica (Oslo, Norway : 1992)en_US
dc.rights.accessNational Consortium - Landsaðganguren_US
dc.departmentcodeOAG12
dc.departmentcodePED12
dc.departmentcodeLYF12
dc.source.journaltitleActa paediatrica (Oslo, Norway : 1992)
dc.source.countryNorway


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