Show simple item record

dc.contributor.authorAuðunsson, A B
dc.contributor.authorElíasson, G J
dc.contributor.authorSteingrímsson, E
dc.contributor.authorAspelund, T
dc.contributor.authorSigurdsson, S
dc.contributor.authorLauner, L
dc.contributor.authorGudnason, V
dc.contributor.authorJonsson, H
dc.date.accessioned2021-04-29T14:29:40Z
dc.date.available2021-04-29T14:29:40Z
dc.date.issued2021-03-07
dc.date.submitted2021-04
dc.identifier.citationAuðunsson AB, Elíasson GJ, Steingrímsson E, Aspelund T, Sigurdsson S, Launer L, Gudnason V, Jonsson H. Diffuse idiopathic skeletal hyperostosis in elderly Icelanders and its association with the metabolic syndrome: the AGES-Reykjavik Study. Scand J Rheumatol. 2021 Mar 7:1-5. doi: 10.1080/03009742.2020.1846779.en_US
dc.identifier.pmid33682605
dc.identifier.doi10.1080/03009742.2020.1846779
dc.identifier.urihttp://hdl.handle.net/2336/621770
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractObjective: To describe the prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in a large population-based study of elderly Icelanders, with particular reference to weight-related factors and the metabolic syndrome.Method: The study population comprised 5321 participants aged 68-96 years (2276 males, mean ± sd age 76 ± 5 , and 3045 females, age 77 ± 6) from the AGES-Reykjavik Study. DISH diagnosis was based on computed tomography (CT) scans, and interpreted strictly by the Resnick criteria and additional suggestions for CT interpretation by Oudkerk et al. Radiology readings were taken by a radiology resident and sample readings by two experienced radiologists.Results: A diagnosis of DISH was made in 13.7% of males and 2.8% of females. There was no association with age, but a strong association was seen with the metabolic syndrome [odds ratio (OR) 2.12, 95% confidence interval (CI) 1.69-2.64, p = 3.9 × 10-11]. Among the components of the metabolic syndrome, the association with DISH was significant for the insulin resistance criterion (OR 1.66, 95% CI 1.32-2.01, p < 0.001) and the body mass index (BMI) criterion (OR 2.16, 95% CI 1.70-2.74, p < 0.001). Other weight-related variables (midlife BMI, weight, and abdominal circumference) showed similar associations.Conclusions: This study, which to our knowledge is the largest published study on the prevalence of DISH, shows an association with the metabolic syndrome, particularly with the insulin resistance and BMI criteria. This is analogous with previous reports linking DISH with metabolic causes. In this age category, we did not observe any increase in prevalence with age.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USAen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.urlhttps://www.tandfonline.com/doi/abs/10.1080/03009742.2020.1846779?journalCode=irhe20en_US
dc.subject.meshHyperostosis, Diffuse Idiopathic Skeletalen_US
dc.titleDiffuse idiopathic skeletal hyperostosis in elderly Icelanders and its association with the metabolic syndrome: the AGES-Reykjavik Study.en_US
dc.typeArticleen_US
dc.identifier.eissn1502-7732
dc.contributor.department1Department of Radiology, Landspitali University Hospital, Reykjavík, Iceland. 2Department of Radiology, Domus Medica, Reykjavík, Iceland. 3Icelandic Heart Association, Kopavogur, Iceland. 4Faculty of Medicine, University of Iceland, Reykjavík, Iceland. 5National Institute on Aging (NIA), National Institutes of Health (NIH), Bethesda, MD, USA. 6Department of Rheumatology, Landspitali University Hospital, Reykjavík, Iceland.en_US
dc.identifier.journalScandinavian journal of rheumatologyen_US
dc.rights.accessClosed - Lokaðen_US
dc.departmentcodeRHE12
dc.source.journaltitleScandinavian journal of rheumatology
dc.source.beginpage1
dc.source.endpage5
dc.source.countryEngland


This item appears in the following Collection(s)

Show simple item record