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dc.contributor.authorModig, Katarina Koss
dc.contributor.authorGodtman, Rebecka Arnsrud
dc.contributor.authorBjartell, Anders
dc.contributor.authorCarlsson, Stefan
dc.contributor.authorHaglind, Eva
dc.contributor.authorHugosson, Jonas
dc.contributor.authorMånsson, Marianne
dc.contributor.authorSteineck, Gunnar
dc.contributor.authorThorsteinsdottir, Thordis
dc.contributor.authorTyritzis, Stavros
dc.contributor.authorLantz, Anna Wallerstedt
dc.contributor.authorWiklund, Peter
dc.contributor.authorStranne, Johan
dc.date.accessioned2021-05-05T09:53:19Z
dc.date.available2021-05-05T09:53:19Z
dc.date.issued2019-11-09
dc.date.submitted2021-05
dc.identifier.citationModig KK, Godtman RA, Bjartell A, Carlsson S, Haglind E, Hugosson J, Månsson M, Steineck G, Thorsteinsdottir T, Tyritzis S, Lantz AW, Wiklund P, Stranne J. Vesicourethral Anastomotic Stenosis After Open or Robot-assisted Laparoscopic Retropubic Prostatectomy-Results from the Laparoscopic Prostatectomy Robot Open Trial. Eur Urol Focus. 2021 Mar;7(2):317-324. doi: 10.1016/j.euf.2019.10.012.en_US
dc.identifier.pmid31711932
dc.identifier.doi10.1016/j.euf.2019.10.012
dc.identifier.urihttp://hdl.handle.net/2336/621780
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractBackground: Vesicourethral anastomotic stenosis is a well-known late complication after open radical retropubic prostatectomy (RRP) with previously reported incidences of 2.7-15%. There are few reports of the incidence after robot-assisted laparoscopic radical prostatectomy (RALP) compared with RRP. Objective: The aim was to compare the risk of developing symptomatic stenosis after RRP and RALP, and to explore potential risk factors and the influence of stenosis on the risk of urinary incontinence. Design, setting, and participants: Between 2008 and 2011, 4003 men were included in a prospective trial comparing RRP and RALP at 14 Swedish centres. Clinical data and patient questionnaires were collected before, during, and after surgery. Outcome measurements and statistical analysis: Stenosis was identified by either patients' reports in questionnaires or case report forms. The primary endpoint is reported as unadjusted as well as adjusted relative risks (RRs), calculated with log-binomial regression models. Data on incontinence were analysed by means of a log-binomial regression model, with stenosis as an independent and incontinence as a dependent variable. Results and limitations: Symptomatic stenosis developed in 1.9% of 3706 evaluable men within 24 mo. The risk was 2.2 times higher after RRP than after RALP (RR 2.21, 95% confidence interval [CI] 1.38-3.53). Overall, urinary incontinence was twice as common in patients who had stenosis (RR 2.01, 95% CI 1.43-2.64). Conclusions: This large prospective study found an overall low rate of vesicourethral anastomotic stenosis after radical prostatectomy, but the rate was significantly lower after robot-assisted prostatectomy. The risk of stenosis seems to be associated with the number of sutures/takes in the anastomosis, but this was statistically significant only in the RALP group. Patient summary: We investigated the risk of developing vesicourethral anastomotic stenosis after open and robot-assisted radical prostatectomy. We found that the risk was generally lower than previously reported and lower after robot-assisted radical prostatectomy than after radical retropubic prostatectomy. Urinary incontinence was twice as common in patients with stenosis. Keywords: Anastomotic stenosis; Prostate cancer; Robotic surgery.en_US
dc.description.sponsorshipSwedish governmenten_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S2405456919303347?via%3Dihuben_US
dc.rightsCopyright © 2019 European Association of Urology. Published by Elsevier B.V. All rights reserved.
dc.subjectAnastomotic stenosisen_US
dc.subjectProstate canceren_US
dc.subjectRobotic surgeryen_US
dc.subjectBlöðruhálskirtilskrabbameinen_US
dc.subjectSkurðlækningaren_US
dc.subject.meshUrethral Strictureen_US
dc.subject.meshProstatic Neoplasmsen_US
dc.subject.meshProstatectomyen_US
dc.titleVesicourethral Anastomotic Stenosis After Open or Robot-assisted Laparoscopic Retropubic Prostatectomy-Results from the Laparoscopic Prostatectomy Robot Open Trial.en_US
dc.typeArticleen_US
dc.identifier.eissn2405-4569
dc.contributor.department1Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: katarina.koss.modig@vgregion.se. 2Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 3Department of Urology, Skåne University Hospital, Malmö, Sweden; Division of Urological Cancers, Department of Translational Medicine, Faculty of Medicine, Lund University, Lund, Sweden. 4Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institute, Stockholm, Sweden. 5Department of Surgery, Institute of Clinical Sciences, Scandinavian Surgical Outcomes Research Group, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 6Division of Clinical Cancer Epidemiology,Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Department of Oncology andPathology, Division of Clinical Cancer Epidemiology, Karolinska Institute, Stockholm, Sweden. 7Research Institute in Emergency Care, Landspitali University Hospital, Reykjavik, Iceland; Faculty of Nursing, University of Iceland, Reykjavik, Iceland. 8Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institute, Stockholm, Sweden; Department of Urology, Hygeia Hospital, Athens, Greece. 9Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institute, Stockholm, Sweden; Icahn School of medicine at Mount Sinai Health System, New York City, NY, USA.en_US
dc.identifier.journalEuropean urology focusen_US
dc.rights.accessNational Consortium - Landsaðganguren_US
dc.departmentcodeEAN12
dc.source.journaltitleEuropean urology focus
dc.source.volume7
dc.source.issue2
dc.source.beginpage317
dc.source.endpage324
dc.source.countryNetherlands


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