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Effect of comorbidities on survival in patients >80 years of age at onset of renal replacement therapy: data from the ERA-EDTA Registry.

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Authors
Helve, Jaakko
Kramer, Anneke
Abad Diez, Jose Maria
Aresté-Fosalba, Nuria
Arici, Mustafa
Cases, Aleix
Collart, Frederic
Heaf, James
de Meester, Johan
Nordio, Maurizio
Palsson, Runolfur
Pobes, Alfonso
Rydell, Helena
Reisæter, Anna Varberg
Massy, Ziad A
Jager, Kitty J
Finne, Patrik
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Issue Date
2021-03

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Citation
Helve J, Kramer A, Abad Diez JM, Aresté-Fosalba N, Arici M, Cases A, Collart F, Heaf J, De Meester J, Nordio M, Palsson R, Pobes A, Rydell H, Reisæter AV, Massy ZA, Jager KJ, Finne P. Effect of comorbidities on survival in patients >80 years of age at onset of renal replacement therapy: data from the ERA-EDTA Registry. Nephrol Dial Transplant. 2021 Mar 29;36(4):688-694. doi: 10.1093/ndt/gfaa278.
Abstract
Background: The number of elderly patients on renal replacement therapy (RRT) is increasing. The survival and quality of life of these patients may be lower if they have multiple comorbidities at the onset of RRT. The aim of this study was to explore whether the effect of comorbidities on survival is similar in elderly RRT patients compared with younger ones. Methods: Included were 9333 patients ≥80 years of age and 48 352 patients 20-79 years of age starting RRT between 2010 and 2015 from 15 national or regional registries submitting data to the European Renal Association-European Dialysis and Transplantation Association Registry. Patients were followed until death or the end of 2016. Survival was assessed by Kaplan-Meier curves and the relative risk of death associated with comorbidities was assessed by Cox regression analysis. Results: Patients ≥80 years of age had a greater comorbidity burden than younger patients. However, relative risks of death associated with all studied comorbidities (diabetes, ischaemic heart disease, chronic heart failure, cerebrovascular disease, peripheral vascular disease and malignancy) were significantly lower in elderly patients compared with younger patients. Also, the increase in absolute mortality rates associated with an increasing number of comorbidities was smaller in elderly patients. Conclusions: Comorbidities are common in elderly patients who enter RRT, but the risk of death associated with comorbidities is less than in younger patients. This should be taken into account when assessing the prognosis of elderly RRT patients. Keywords: ESKD; comorbidity; elderly; renal replacement therapy; survival.
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https://academic.oup.com/ndt/article/36/4/688/6127567
Rights
© The Author(s) 2021. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
ae974a485f413a2113503eed53cd6c53
10.1093/ndt/gfaa278
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English Journal Articles (Peer Reviewed)

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