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Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies.

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Authors
Rögnvaldsson, Sæmundur
Love, Thorvardur Jon
Thorsteinsdottir, Sigrun
Reed, Elín Ruth
Óskarsson, Jón Þórir
Pétursdóttir, Íris
Sigurðardóttir, Guðrún Ásta
Viðarsson, Brynjar
Önundarson, Páll Torfi
Agnarsson, Bjarni A
Sigurðardóttir, Margrét
Þorsteinsdóttir, Ingunn
Ólafsson, Ísleifur
Þórðardóttir, Ásdís Rósa
Eyþórsson, Elías
Jónsson, Ásbjörn
Björnsson, Andri S
Gunnarsson, Gunnar Þór
Pálsson, Runólfur
Indriðason, Ólafur Skúli
Gíslason, Gauti Kjartan
Ólafsson, Andri
Hákonardóttir, Guðlaug Katrín
Brinkhuis, Manje
Halldórsdóttir, Sara Lovísa
Ásgeirsdóttir, Tinna Laufey
Steingrímsdóttir, Hlíf
Danielsen, Ragnar
Dröfn Wessman, Inga
Kampanis, Petros
Hulcrantz, Malin
Durie, Brian G M
Harding, Stephen
Landgren, Ola
Kristinsson, Sigurður Yngvi
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Issue Date
2021-05-17

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Rögnvaldsson S, Love TJ, Thorsteinsdottir S, Reed ER, Óskarsson JÞ, Pétursdóttir Í, Sigurðardóttir GÁ, Viðarsson B, Önundarson PT, Agnarsson BA, Sigurðardóttir M, Þorsteinsdóttir I, Ólafsson Í, Þórðardóttir ÁR, Eyþórsson E, Jónsson Á, Björnsson AS, Gunnarsson GÞ, Pálsson R, Indriðason ÓS, Gíslason GK, Ólafsson A, Hákonardóttir GK, Brinkhuis M, Halldórsdóttir SL, Ásgeirsdóttir TL, Steingrímsdóttir H, Danielsen R, Dröfn Wessman I, Kampanis P, Hulcrantz M, Durie BGM, Harding S, Landgren O, Kristinsson SY. Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies. Blood Cancer J. 2021 May 17;11(5):94. doi: 10.1038/s41408-021-00480-w.
Abstract
Monoclonal gammopathy of undetermined significance (MGUS) precedes multiple myeloma (MM). Population-based screening for MGUS could identify candidates for early treatment in MM. Here we describe the Iceland Screens, Treats, or Prevents Multiple Myeloma study (iStopMM), the first population-based screening study for MGUS including a randomized trial of follow-up strategies. Icelandic residents born before 1976 were offered participation. Blood samples are collected alongside blood sampling in the Icelandic healthcare system. Participants with MGUS are randomized to three study arms. Arm 1 is not contacted, arm 2 follows current guidelines, and arm 3 follows a more intensive strategy. Participants who progress are offered early treatment. Samples are collected longitudinally from arms 2 and 3 for the study biobank. All participants repeatedly answer questionnaires on various exposures and outcomes including quality of life and psychiatric health. National registries on health are cross-linked to all participants. Of the 148,704 individuals in the target population, 80 759 (54.3%) provided informed consent for participation. With a very high participation rate, the data from the iStopMM study will answer important questions on MGUS, including potentials harms and benefits of screening. The study can lead to a paradigm shift in MM therapy towards screening and early therapy.
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To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download
Additional Links
https://www.nature.com/articles/s41408-021-00480-w
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128921/
ae974a485f413a2113503eed53cd6c53
10.1038/s41408-021-00480-w
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