Endothelial dysfunction and thromboembolism in children, adolescents, and young adults with acute lymphoblastic leukemia.
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Rank, Cecilie Utke
Albertsen, Birgitte Klug
Linnemann Nielsen, Rikke
Lynggaard, Line Stensig
Jarvis, Kirsten Brunsvig
Trakymiene, Sonata Saulyte
Jonsson, Olafur Gisli
Frandsen, Thomas Leth
Johansson, Pär Ingemar
MetadataShow full item record
CitationAndrés-Jensen L, Grell K, Rank CU, Albertsen BK, Tuckuviene R, Linnemann Nielsen R, Lynggaard LS, Jarvis KB, Quist-Paulsen P, Trakymiene SS, Semaškevičienė R, Saks K, Jonsson OG, Frandsen TL, Johansson PI, Schmiegelow K. Endothelial dysfunction and thromboembolism in children, adolescents, and young adults with acute lymphoblastic leukemia. Leukemia. 2021 Aug 13. doi: 10.1038/s41375-021-01383-2.
ÚtdrátturEndothelial dysfunction has not previously been investigated as a thrombogenic risk factor among patients with acute lymphoblastic leukemia (ALL), known to be at high risk of thromboembolism. We retrospectively explored the association between three circulating biomarkers of endothelial dysfunction (thrombomodulin, syndecan-1, VEGFR-1) measured in prospectively collected blood samples and risk of thromboembolism in 55 cases and 165 time-matched controls, treated according to the NOPHO ALL2008 protocol. In age-, sex-, and risk group-adjusted analysis, increasing levels of thrombomodulin and VEGFR-1 were independently associated with increased odds of developing thromboembolism (OR 1.37 per 1 ng/mL [95% CI 1.20‒1.56, P < 0.0001] and OR 1.21 per 100 pg/mL [95% CI 1.02‒1.21, P = 0.005], respectively). These associations remained significant when including only samples drawn >30 days before thromboembolic diagnosis. Thrombomodulin levels were on average 3.2 ng/mL (95% CI 2.6-8.2 ng/mL) higher in samples with measurable asparaginase activity (P < 0.0001). Among single nucleotide variants located in or neighboring coding genes for the three biomarkers, none were significantly associated with odds of thromboembolism. If results are validated in another cohort, thrombomodulin and VEGFR-1 could serve as predictive biomarkers, identifying patients in need of preemptive antithrombotic prophylaxis.
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Rights© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
- Thromboembolism in acute lymphoblastic leukemia: results of NOPHO ALL2008 protocol treatment in patients aged 1 to 45 years.
- Authors: Rank CU, Toft N, Tuckuviene R, Grell K, Nielsen OJ, Frandsen TL, Marquart HVH, Albertsen BK, Tedgård U, Hallböök H, Ruud E, Jarvis KB, Quist-Paulsen P, Huttunen P, Wartiovaara-Kautto U, Jónsson ÓG, Trakymiene SS, Griškevičius L, Saks K, Punab M, Schmiegelow K
- Issue date: 2018 May 31
- Asparaginase Enzyme Activity Levels and Toxicity in Childhood Acute Lymphoblastic Leukemia: a NOPHO ALL2008 study.
- Authors: Lynggaard LS, Rank CU, Hansen SN, Gottschalk Højfeldt S, Henriksen LT, Jarvis KB, Ranta S, Niinimäki R, Harila-Saari A, Wolthers BO, Frandsen TL, Heyman M, Schmiegelow K, Albertsen BK
- Issue date: 2021 Oct 8
- Candidate single nucleotide polymorphisms and thromboembolism in acute lymphoblastic leukemia - A NOPHO ALL2008 study.
- Authors: Jarvis KB, LeBlanc M, Tulstrup M, Nielsen RL, Albertsen BK, Gupta R, Huttunen P, Jónsson ÓG, Rank CU, Ranta S, Ruud E, Saks K, Trakymiene SS, Tuckuviene R, Schmiegelow K
- Issue date: 2019 Dec
- Asparaginase-Associated Pancreatitis in Acute Lymphoblastic Leukemia: Results From the NOPHO ALL2008 Treatment of Patients 1-45 Years of Age.
- Authors: Rank CU, Wolthers BO, Grell K, Albertsen BK, Frandsen TL, Overgaard UM, Toft N, Nielsen OJ, Wehner PS, Harila-Saari A, Heyman MM, Malmros J, Abrahamsson J, Norén-Nyström U, Tomaszewska-Toporska B, Lund B, Jarvis KB, Quist-Paulsen P, Vaitkevičienė GE, Griškevičius L, Taskinen M, Wartiovaara-Kautto U, Lepik K, Punab M, Jónsson ÓG, Schmiegelow K
- Issue date: 2020 Jan 10
- Pulmonary embolism in acute lymphoblastic leukemia - An observational study of 1685 patients treated according to the NOPHO ALL2008 protocol.
- Authors: Tuckuviene R, Bjerg CL, Jonsson OG, Langstrom S, Rank CU, Ranta S, Saks K, Trakymiene SS, Ruud E
- Issue date: 2020 Jul