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Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model Reconstruction.

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Authors
Sigmarsdottir, Thora Bjorg
McGarrity, Sarah
Yurkovich, James T
Rolfsson, Óttar
Sigurjónsson, Ólafur Eysteinn
Issue Date
2021-06-04

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Sigmarsdottir TB, McGarrity S, Yurkovich JT, Rolfsson Ó, Sigurjónsson ÓE. Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model Reconstruction. Front Cell Dev Biol. 2021;9:642681. Published 2021 Jun 4. doi:10.3389/fcell.2021.642681
Abstract
Since their initial discovery in 1976, mesenchymal stem cells (MSCs) have been gathering interest as a possible tool to further the development and enhancement of various therapeutics within regenerative medicine. However, our current understanding of both metabolic function and existing differences within the varying cell lineages (e.g., cells in either osteogenesis or adipogenesis) is severely lacking making it more difficult to fully realize the therapeutic potential of MSCs. Here, we reconstruct the MSC metabolic network to understand the activity of various metabolic pathways and compare their usage under different conditions and use these models to perform experimental design. We present three new genome-scale metabolic models (GEMs) each representing a different MSC lineage (proliferation, osteogenesis, and adipogenesis) that are biologically feasible and have distinctive cell lineage characteristics that can be used to explore metabolic function and increase our understanding of these phenotypes. We present the most distinctive differences between these lineages when it comes to enriched metabolic subsystems and propose a possible osteogenic enhancer. Taken together, we hope these mechanistic models will aid in the understanding and therapeutic potential of MSCs. Keywords: GEM; MSCs; adipogenesis; metabolic differences; metabolic reconstruction; osteogenesis.
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https://www.frontiersin.org/articles/10.3389/fcell.2021.642681/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212021/
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Copyright © 2021 Sigmarsdottir, McGarrity, Yurkovich, Rolfsson and Sigurjónsson.
ae974a485f413a2113503eed53cd6c53
10.3389/fcell.2021.642681
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