Higher Alkylresorcinol Concentrations, a Consequence of Whole-Grain Intake, are Inversely Associated with Gestational Diabetes Mellitus in Iceland.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsTryggvadottir, Ellen A
Halldorsson, Thorhallur I
Birgisdottir, Bryndis E
Magnusdottir, Ola K
Hreidarsdottir, Ingibjorg T
MetadataShow full item record
CitationTryggvadottir EA, Halldorsson TI, Landberg R, et al. Higher Alkylresorcinol Concentrations, a Consequence of Whole-Grain Intake, are Inversely Associated with Gestational Diabetes Mellitus in Iceland. J Nutr. 2021;151(5):1159-1166. doi:10.1093/jn/nxaa449
AbstractBackground: A diet rich in whole grains may provide benefits for pregnant women due to whole grains' high nutritional value and dietary fiber content. Objectives: To study the associations of whole-grain consumption, as well as the plasma alkylresorcinol concentration, a whole-grain consumption biomarker, in early pregnancy with gestational diabetes mellitus (GDM) diagnoses. Methods: Subjects were women from the prospective study Pregnant Women in Iceland II (PREWICE II; n = 853) who attended their ultrasound appointment in gestational weeks 11-14 during the period from October 2017 to March 2018. During that visit, whole-grain consumption was estimated using a diet screening questionnaire, and blood samples were collected for analysis of plasma alkylresorcinols (ARs). Information on GDM diagnoses was later extracted from medical records. Multivariate log-binomial regression was used to evaluate the association of dietary whole-grain and AR concentrations with GDM. Results: In total, 14.9% of the women adhered to the national food-based dietary guidelines (n = 127), which recommend 2 portions of whole grains daily. GDM was diagnosed in 127 women (14.9%). The frequency of whole-grain consumption was lower in women who were later diagnosed with GDM compared to the women without GDM (median, 5 times/week vs. 6 times/week, respectively; P = 0.02). This difference was reflected in the lower median concentration of total AR in women diagnosed with GDM (163 nmol/L vs. 209 nmol/L, respectively; P < 0.01). The quartile with the highest concentrations of AR had a RR of 0.50 (95% CI: 0.27-0.90) of being diagnosed with GDM, in comparison to the lowest quartile. There was a significant dose response in the GDM risk with higher AR levels. Conclusions: We found that a higher consumption of whole grains, reflected both by reported consumption according to the FFQ and AR biomarkers, was associated with a decreased risk of receiving a GDM diagnosis.
DescriptionTo access publisher's full text version of this article click on the hyperlink below
Rights© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
- Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and risk of type 2 diabetes in Scandinavian men and women.
- Authors: Biskup I, Kyrø C, Marklund M, Olsen A, van Dam RM, Tjønneland A, Overvad K, Lindahl B, Johansson I, Landberg R
- Issue date: 2016 Jul
- Whole grain intake, determined by dietary records and plasma alkylresorcinol concentrations, is low among pregnant women in Singapore.
- Authors: Ross AB, Colega MT, Lim AL, Silva-Zolezzi I, Macé K, Saw SM, Kwek K, Gluckman P, Godfrey KM, Chong YS, Chong MF
- Issue date: 2015
- Risk of gestational diabetes mellitus in relation to maternal dietary calcium intake.
- Authors: Osorio-Yáñez C, Qiu C, Gelaye B, Enquobahrie DA, Williams MA
- Issue date: 2017 Apr
- Dietary intake of whole grains and plasma alkylresorcinol concentrations in relation to changes in anthropometry: the Danish diet, cancer and health cohort study.
- Authors: Kyrø C, Kristensen M, Jakobsen MU, Halkjær J, Landberg R, Bueno-de-Mesquita HA, Christensen J, Romieu I, Tjønneland A, Olsen A
- Issue date: 2017 Aug
- Early pregnancy plasma fatty acid profiles of women later diagnosed with gestational diabetes.
- Authors: Tryggvadottir EA, Gunnarsdottir I, Birgisdottir BE, Hrolfsdottir L, Landberg R, Hreidarsdottir IT, Hardardottir H, Halldorsson TI
- Issue date: 2021 Aug