The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice
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Authors
Forzano, FrancescaAntonova, Olga
Clarke, Angus
de Wert, Guido
Hentze, Sabine
Jamshidi, Yalda
Moreau, Yves
Perola, Markus
Prokopenko, Inga
Read, Andrew
Reymond, Alexandre
Stefansdottir, Vigdis
van El, Carla
Genuardi, Maurizio
Peterlin, Borut
Oliveira, Carla
Writzl, Karin
Houge, Gunnar Douzgos
Cordier, Christophe
Howard, Heidi
Macek, Milan
Melegh, Béla
Mendes, Alvaro
Radojkovic, Dragica
Rial-Sebbag, Emmanuelle
Ulph, Fiona
Jamshidi, Yalda
Issue Date
2021-12-17
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Forzano F, Antonova O, Clarke A, de Wert G, Hentze S, Jamshidi Y, et al. The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice. Eur J Hum Genet.doi:10.1038/s41431-021-01000-x.Abstract
Y Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful in selecting the embryos that carry the least risk of disease in later life. It appears that at least one child has been born after such a procedure. But the utility of a PRS in this respect is severely limited, and to date, no clinical research has been performed to assess its diagnostic effectiveness in embryos. Patients need to be properly informed on the limitations of this use of PRSs, and a societal debate, focused on what would be considered acceptable with regard to the selection of individual traits, should take place before any further implementation of the technique in this population.Description
To access publisher's full text version of this article click on the hyperlink belowAdditional Links
https://www.nature.com/articles/s41431-021-01000-xae974a485f413a2113503eed53cd6c53
10.1038/s41431-021-01000-x
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