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dc.contributor.authorOmarsdottir, S
dc.contributor.authorFreysdottir, J
dc.contributor.authorBarsett, H
dc.contributor.authorPaulsen, B Smestad
dc.contributor.authorOlafsdottir, E S
dc.date.accessioned2009-04-17T11:51:50Z
dc.date.available2009-04-17T11:51:50Z
dc.date.issued2005-06-01
dc.date.submitted2009-04-17
dc.identifier.citationPhytomedicine. 2005, 12(6-7):461-7en
dc.identifier.issn0944-7113
dc.identifier.pmid16008123
dc.identifier.doi10.1016/j.phymed.2004.03.012
dc.identifier.urihttp://hdl.handle.net/2336/65232
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractFour polysaccharides Pc-1, Pc-2, Pc-3 and Pc-4 were isolated from water and alkali extracts of the lichen Peltigera canina using ethanol fractionation, gel filtration and preparative HP-GPC. The monosaccharide composition was determined by methanolysis and GC and showed mannose and galactose as the predominating structural units. The mean M(r) was determined by HP-GPC. The heteroglycans were tested for in vitro immunomodulating activities and showed mitogenic activity in rat spleen cell proliferation assay and stimulated IL-10 secretion. In rat peritoneal macrophages, the heteroglycans stimulated TNF-alpha secretion, but not IL-10 secretion. These results indicate that the polysaccharides influence cells of the immune system both from the innate and the adaptive systems.
dc.language.isoenen
dc.publisherUrban & Fischer Verlagen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B7GVW-4G3CWSR-5/2/273a0225747294aa1dda7671df2b3d60en
dc.subject.meshAnimalsen
dc.subject.meshCell Proliferationen
dc.subject.meshFemaleen
dc.subject.meshImmunologic Factorsen
dc.subject.meshInterleukin-10en
dc.subject.meshLichensen
dc.subject.meshMacrophages, Peritonealen
dc.subject.meshPhytotherapyen
dc.subject.meshPlant Extractsen
dc.subject.meshRatsen
dc.subject.meshRats, Inbred Lewen
dc.subject.meshSpleenen
dc.subject.meshTumor Necrosis Factor-alphaen
dc.titleEffects of lichen heteroglycans on proliferation and IL-10 secretion by rat spleen cells and IL-10 and TNF-alpha secretion by rat peritoneal macrophages in vitroen
dc.typeArticleen
dc.contributor.departmentFaculty of Pharmacy, University of Iceland, Hagi, Hofsvallagata 53, IS-107 Reykjavik, Iceland.en
dc.identifier.journalPhytomedicine : international journal of phytotherapy and phytopharmacologyen
html.description.abstractFour polysaccharides Pc-1, Pc-2, Pc-3 and Pc-4 were isolated from water and alkali extracts of the lichen Peltigera canina using ethanol fractionation, gel filtration and preparative HP-GPC. The monosaccharide composition was determined by methanolysis and GC and showed mannose and galactose as the predominating structural units. The mean M(r) was determined by HP-GPC. The heteroglycans were tested for in vitro immunomodulating activities and showed mitogenic activity in rat spleen cell proliferation assay and stimulated IL-10 secretion. In rat peritoneal macrophages, the heteroglycans stimulated TNF-alpha secretion, but not IL-10 secretion. These results indicate that the polysaccharides influence cells of the immune system both from the innate and the adaptive systems.


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