Dorzolamide increases retinal oxygen tension after branch retinal vein occlusion
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Noergaard, Michael HoveBach-Holm, Daniella
Scherfig, Erik
Bang, Kurt
Jensen, Peter Koch
Kiilgaard, Jens Folke
Stefansson, Einar
la Cour, Morten
Issue Date
2008-03-01
Metadata
Show full item recordCitation
Invest. Ophthalmol. Vis. Sci. 2008, 49(3):1136-41Abstract
PURPOSE: To study the effect of dorzolamide on the preretinal oxygen tension (RPO(2)) in retinal areas affected by experimental branch retinal vein occlusion (BRVO) in pigs. METHODS: Experimental BRVO was induced by diathermy close to the optic disc. RPO(2) was measured with an oxygen-sensitive electrode 0.5 mm above the BRVO-affected area, which was compared to the retinal areas not affected by BRVO. In one group of five pigs, RPO(2) was measured at baseline, 1 and 3 hours after BRVO, and after intravenous injection of 500 mg dorzolamide. In a second group of five pigs, RPO(2) was measured 1 week after the BRVO, both before and after intravenous injection of 500 mg dorzolamide. RESULTS: The average baseline RPO(2) was 2.64 +/- 0.09 kPa (mean +/- SD). In the BRVO-affected areas, RPO(2) decreased significantly (by 0.67 +/- 0.29 and 0.94 +/- 0.13 kPa) at 1 hour and 3 hours after BRVO induction. In the non-BRVO areas RPO(2) increased significantly (by 0.51 +/- 0.14 kPa) 1 hour after BRVO induction, but subsequently decreased and reached baseline 3 hours after BRVO induction. One week after BRVO induction, RPO(2) was 0.67 +/- 0.29 kPa lower in affected areas when compared with the non-BRVO areas. In the BRVO-affected areas, dorzolamide increased RPO(2) significantly (by 0.36 +/- 0.21 kPa at 3 to 4 hours and by 0.67 +/- 0.40 kPa) 1 week after BRVO induction. CONCLUSIONS: Retinal hypoxia induced by experimental BRVO remained significant 1 week after BRVO. Dorzolamide increased retinal oxygen tension in the BRVO-affected areas both at 4 hours and 1 week after experimental BRVO in pigs.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAdditional Links
http://www.iovs.org/cgi/content/abstract/49/3/1136ae974a485f413a2113503eed53cd6c53
10.1167/iovs.07-0508
Scopus Count
Collections
Related articles
- Electrophysiological consequences of experimental branch retinal vein occlusion in pigs and the effect of dorzolamide.
- Authors: Ejstrup R, Scherfig E, la Cour M
- Issue date: 2011 Feb 16
- Experimental retinal vein occlusion: effect of acetazolamide and carbogen (95% O2/5% CO2) on preretinal PO2.
- Authors: Pournaras JA, Petropoulos IK, Munoz JL, Pournaras CJ
- Issue date: 2004 Oct
- Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels.
- Authors: Pedersen DB, Koch Jensen P, la Cour M, Kiilgaard JF, Eysteinsson T, Bang K, Wiencke AK, Stefánsson E
- Issue date: 2005 Feb
- [Experimental branch vein occlusion: the effect of carbogen breathing on preretinal PO2].
- Authors: Pournaras JA, Poitry S, Munoz JL, Pournaras CJ
- Issue date: 2003 Oct
- Optic nerve oxygen tension: effects of intraocular pressure and dorzolamide.
- Authors: la Cour M, Kiilgaard JF, Eysteinsson T, Wiencke AK, Bang K, Dollerup J, Jensen PK, Stefánsson E
- Issue date: 2000 Sep