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Clinical and cytogenetic features of pediatric dic(9;20)(p13.2;q11.2)-positive B-cell precursor acute lymphoblastic leukemias: a Nordic series of 24 cases and review of the literature

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Authors
Forestier, Erik
Gauffin, Fredrika
Andersen, Mette K
Autio, Kirsi
Borgström, Georg
Golovleva, Irina
Gustafsson, Britt
Heim, Sverre
Heinonen, Kristina
Heyman, Mats
Hovland, Randi
Johannsson, Johann H
Kerndrup, Gitte
Rosenquist, Richard
Schoumans, Jacqueline
Swolin, Birgitta
Johansson, Bertil
Nordgren, Ann
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Issue Date
2008-02-01

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Citation
Genes Chromosomes Cancer. 2008, 47(2):149-58
Abstract
Although dic(9;20)(p13.2;q11.2) is a characteristic abnormality in childhood B-cell precursor acute lymphoblastic leukemias (BCP ALL), little is known about its clinical impact or the type and frequency of additional aberrations it may occur together with. We here review the clinical and cytogenetic features of a Nordic pediatric series of 24 patients with dic(9;20)-positive BCP ALL diagnosed 1996-2006, constituting 1.3% of the BCP ALL, as well as 47 childhood cases from the literature. Consistent immunophenotypic features of the Nordic cases included positivity for HLA-DR, CD10, CD19, CD20, and CD22 and negativity for T-cell and myeloid markers; no detailed immunophenotypes were reported for the previously published cases. In the entire cohort of 71 cases, the modal chromosome distribution was 45 (62%), 46 (21%), 47 (7%), 48 (4%), 49 (3%), 44 (1%), and 50 (1%). Additional changes were present in 63%, the most frequent of which were homozygous loss of CDKN2A (33%) and gains of chromosomes 21 (28%) and X (10%). The median patient age was 3 years, the female/male ratio was 2.0, the median white blood cell count was 24 x 10(9)/l, 11% had central nervous system involvement, and 5% had a mediastinal mass at diagnosis. Risk group stratification was nonstandard risk in 79%. The event-free survival and overall survival at 5 years for the 24 Nordic cases was 0.62 and 0.82, respectively. Thus, although relapses are quite common, postrelapse treatment of many patients is successful.
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http://dx.doi.org/10.1002/gcc.20517
ae974a485f413a2113503eed53cd6c53
10.1002/gcc.20517
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