No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Gurling, H M
MetadataShow full item record
CitationPsychiatr. Genet. 1999, 9(4):197-9
AbstractThere have been claims that a gene on the X chromosome may contribute to susceptibility to schizophrenia. Crow (1988) initially proposed that such a gene might lie in the pseudoautosomal region, but when evidence that weakened this hypothesis accumulated, he proposed that a susceptibility locus might be present elsewhere on the sex chromosomes instead. DeLisi et al. (1994) found a small nonsignificant positive lod score between the marker DXS7 and schizophrenia, but other failed to replicate this finding. Another study reported by Crow and DeLisi's group was also weakly positive for this marker (Dann et al., 1997). This locus was then investigated in a collaborative study by Laval et al. (1997), which produced a nonparametric lod score of 2.44. Using a sample of 17 pedigrees from Britain and Iceland, we have also tested the hypothesis of linkage between DXS7 and schizophrenia. The 17 families were selected from a larger sample on the basis of an absence of male-to-male transmission for schizophrenia. These families were originally selected for having multiple cases of schizophrenia within them and for having no cases of bipolar affective disorder. We genotyped subjects for a marker at DXS7 and performed classical lod score and model-free linkage analysis using broad and narrow definitions of affection with schizophrenia. We found strongly negative lod scores and no evidence for linkage using model-free analysis. Therefore, this study does not support the hypothesis of linkage of schizophrenia to DXS7, and the evidence for a susceptibility locus on this part of the X chromosome is weakened.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- No evidence for linkage between the X-chromosome marker DXS7 and schizophrenia.
- Authors: Okoro C, Bell R, Sham P, Nanko S, Asherson P, Owen M, Gill M, McGuffin P, Murray RM, Collier D
- Issue date: 1995 Oct 9
- Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23.
- Authors: Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, McQuillin A, Petursson H, Curtis D
- Issue date: 2001 Mar
- Search for linkage to schizophrenia on the X and Y chromosomes.
- Authors: DeLisi LE, Devoto M, Lofthouse R, Poulter M, Smith A, Shields G, Bass N, Chen G, Vita A, Morganti C
- Issue date: 1994 Jun 15
- A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder.
- Authors: Asherson P, Mant R, Williams N, Cardno A, Jones L, Murphy K, Collier DA, Nanko S, Craddock N, Morris S, Muir W, Blackwood B, McGuffin P, Owen MJ
- Issue date: 1998 Jul
- Linkage analysis of chromosome 22q12-13 in a United Kingdom/Icelandic sample of 23 multiplex schizophrenia families.
- Authors: Kalsi G, Brynjolfsson J, Butler R, Sherrington R, Curtis D, Sigmundsson T, Read T, Murphy P, Sharma T, Petursson H
- Issue date: 1995 Aug 14