Risk profiles and prognosis of treated and untreated hypertensive men and women in a population-based longitudinal study: the Reykjavik Study
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationJ Hum Hypertens. 2004, 18(9):615-22
AbstractThe aim was to examine the risk profiles and prognosis of treated and untreated hypertensive subjects and examine to what degree confounding by indication was present in a population-based cohort study with up to 30-year follow-up. The study population consisted of 9328 men and 10 062 women, aged 33-87 years at the time of attendance from 1967 to 1996. The main outcome measures were myocardial infarction (MI), cardiovascular disease (CVD) mortality and all-cause mortality. Comparing the risk profiles between treated and untreated subjects entering the study showed significantly higher values for some risk factors for treated subjects. During the first 10 years, hypertensive men without treatment, compared with those treated, had a significantly lower risk of suffering MI, CVD and all-cause mortality, hazard ratio (HR) 0.72 (95% CI; 0.57, 0.90), 0.75 (95% CI; 0.59, 0.95) and 0.81 (95% CI; 0.61, 0.98), respectively. No significant differences in outcome were seen during the following 20 years. In identically defined groups of women, no significant differences in mortality were seen between groups. Subgroup analysis, at two stages of the study 5 years apart, revealed that some cardiovascular risk factors had a higher prevalence in hypertensive men who were treated at the later stage, compared with those who remained untreated (P=0.004). In conclusion, hypertensive treated men had a worse prognosis during the first 10 years of follow-up than untreated ones, which is most likely due to worse baseline risk profile. Hypertensive men that were treated at a later stage had a worse risk profile than those not treated at a later stage.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Stroke and coronary heart disease in treated hypertension -- a prospective cohort study over three decades.
- Authors: Almgren T, Persson B, Wilhelmsen L, Rosengren A, Andersson OK
- Issue date: 2005 Jun
- The effects of awareness, treatment and control of hypertension on cardiovascular and all-cause mortality in a community-based population.
- Authors: Barengo NC, Kastarinen M, Antikainen R, Nissinen A, Tuomilehto J
- Issue date: 2009 Dec
- Antihypertensive treatment alters the predictive strength of pulse pressure and other blood pressure measures.
- Authors: Greenberg J
- Issue date: 2005 Aug
- Blood pressure measures and electrocardiogram-defined myocardial infarction in an Iranian population: Tehran Lipid and Glucose study.
- Authors: Ghanbarian A, Rashidi A, Madjid M, Azizi F
- Issue date: 2004 Feb
- Why cardiovascular mortality is higher in treated hypertensives versus subjects of the same age, in the general population.
- Authors: Benetos A, Thomas F, Bean KE, Guize L
- Issue date: 2003 Sep