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dc.contributor.authorSigurdsson, Steinthor
dc.contributor.authorOgmundsdottir, Helga M
dc.contributor.authorHallgrimsson, Jonas
dc.contributor.authorGudbjarnason, Sigmundur
dc.date.accessioned2009-05-18T11:35:50Z
dc.date.available2009-05-18T11:35:50Z
dc.date.issued2005-01-01
dc.date.submitted2009-05-18
dc.identifier.citationIn Vivo 2005, 19(1):191-4en
dc.identifier.issn0258-851X
dc.identifier.pmid15796173
dc.identifier.urihttp://hdl.handle.net/2336/68436
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: The purpose of this study was to examine the effect of a leaf extract from A. archangelica on the growth of Crl mouse breast cancer cells in vitro and in vivo. Materials and METHODS: The antiproliferative activity of the extract was measured by 3H-thymidine uptake in the Crl cells in vitro. Twenty mice were injected with the Crl cells, and 11 of them were fed A. archangelica leaf extract, and the progress of the tumours was followed. RESULTS: The leaf extract was mildly antiproliferative on the Crl cells with an EC50 of 87.6 microg/ml The antitumour activity of the extract was expressed in the mice by marked reduction in tumour growth. In the experimental animals, 9 out of 11 mice developed no or very small tumours, whereas control animals, not receiving the extract, developed significantly larger tumours (p<0.01), as estimated by Mann-Whitney U-test. The antitumour activity of the leaf extract could not be explained by the antiproliferative activity of furanocoumarins present in the extract. CONCLUSION: The results demonstrate the antiproliferative activity in vitro and antitumour activity in vivo of a leaf extract from A. archangelica
dc.language.isoenen
dc.publisherDr. J.G. Delinassiosen
dc.relation.urlhttp://iv.iiarjournals.org/content/19/1/191.abstracten
dc.subject.meshAdministration, Oralen
dc.subject.meshAngelica archangelicaen
dc.subject.meshAnimalsen
dc.subject.meshAntineoplastic Agentsen
dc.subject.meshBreast Neoplasmsen
dc.subject.meshCell Divisionen
dc.subject.meshFemaleen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred BALB Cen
dc.subject.meshNeoplasm Transplantationen
dc.subject.meshPhytotherapyen
dc.subject.meshPlant Extractsen
dc.subject.meshPlant Leavesen
dc.subject.meshThymidineen
dc.subject.meshTransplantation, Isogeneicen
dc.subject.meshTritiumen
dc.subject.meshTumor Cells, Cultureden
dc.titleAntitumour activity of Angelica archangelica leaf extracten
dc.typeArticleen
dc.contributor.departmentScience Institute, University of Iceland, Vatnsmyrarvegur 16, Reykjavik, Iceland. sts@raunvis.hi.isen
dc.identifier.journalIn vivo (Athens, Greece)en
html.description.abstractBACKGROUND: The purpose of this study was to examine the effect of a leaf extract from A. archangelica on the growth of Crl mouse breast cancer cells in vitro and in vivo. Materials and METHODS: The antiproliferative activity of the extract was measured by 3H-thymidine uptake in the Crl cells in vitro. Twenty mice were injected with the Crl cells, and 11 of them were fed A. archangelica leaf extract, and the progress of the tumours was followed. RESULTS: The leaf extract was mildly antiproliferative on the Crl cells with an EC50 of 87.6 microg/ml The antitumour activity of the extract was expressed in the mice by marked reduction in tumour growth. In the experimental animals, 9 out of 11 mice developed no or very small tumours, whereas control animals, not receiving the extract, developed significantly larger tumours (p<0.01), as estimated by Mann-Whitney U-test. The antitumour activity of the leaf extract could not be explained by the antiproliferative activity of furanocoumarins present in the extract. CONCLUSION: The results demonstrate the antiproliferative activity in vitro and antitumour activity in vivo of a leaf extract from A. archangelica


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