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Áhrif kaffis og tes á neðri vélinda hringvöðva

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Authors
Hallgrímur Guðjónsson
McAuliffe, Thimothy
Kaye, Michael D
Útgáfudagur
1995-06-01

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The effect of coffee and tea upon lower esophageal sphincteric function
Citation
Læknablaðið 1995, 81(6):484-8
Útdráttur
The effects of coffee and tea upon lower esophageal sphincteric (LES) function were examined in a blinded crossover study of 12 healthy subjects. Lower esophageal sphincter pressure (LESP) and lower esophageal (LE) pH were measured simultaneously by a sleeve sensor and a pH probe for 20 minutes before and 90 minutes after intragastric instillation of four test solutions, which contained either regular coffee (C), decaffeinated coffee (D), tea (T) or water (W). C and T solutions had the same caffeine content, 160 mg. As compared with control (W), LESP was significantly lower after C and T, but not after D. The data for LE pH paralleled those for LESP. Thus, the greatest number of reflux episodes occurred after T and C. Difference from control (W) was statistically significant for T but not for C. We conclude that both regular coffee and tea have adverse effects upon LES function, whereas decaffeinated coffee does not. This study provides a rational basis for limiting intake of both caffeinated coffee and tea in patients with clinically important gastroesophageal reflux.
Áhrif kaffis og tes á neðri vélinda hringvöðva (lower esophageal sphincter, LES) voru athuguð í blint víxlaðri (blinded cross over) rannsókn á 12 heilbrigðum einstaklingum. Þrýstingur í neðri vélinda hringvöðva (LES pressure, LESP) og sýrumæling (pH) í vélinda var gerð samtímis með belglaga þrýstingsnema og pH skynjara í 20 mínútur fyrir og 90 mínútur eftir innspýtingu á fjórum tilraunarlausnum sem innihéldu ýmist koffínríkt kaffi (C), koffínsnautt kaffi (D), te (T) eða vatn (W). C ogT höfðu sama koffíninnihald, 160 mg. Borið saman við viðmiðunarblöndu (W), þá var þrýstingur neðri vélinda hringvöðva marktækt lægri eftir C og T, en ekki eftir D. Niðurstöður sýrumælinga voru í takt við þrýstingsmælingarnar, þannig að bakflæði átti sér oftast stað eftir C og T. Samanburður við W var marktækur hvað varðar T en ekki C. Við ályktum að bæði venjulegt koffínríkt kaffi og te orsaki vanstarfsemi á neðri vélinda hringvöðva, en koffínsnautt kaffi geri það ekki. Þessi rannsókn leiðir rök að því að sjúklingar með bólgu í vélinda vegna bakflæðis takmarki neyslu bæði á koffínríku kaffi og te.
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