• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Decreasing gut wall glucose as an early marker of impaired intestinal perfusion

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Krejci, Vladimir
Hiltebrand, Luzius
Büchi, Conradin
Ali, Syed Z
Contaldo, Claudio
Takala, Jukka
Sigurdsson, Gisli H
Jakob, Stephan M
Issue Date
2006-09-01

Metadata
Show full item record
Citation
Crit. Care Med. 2006, 34(9):2406-14
Abstract
OBJECTIVE: The aim of this study was to assess the microcirculatory and metabolic consequences of reduced mesenteric blood flow. DESIGN: Prospective, controlled animal study. SETTING: The surgical research unit of a university hospital. SUBJECTS: A total of 13 anesthetized and mechanically ventilated pigs. INTERVENTIONS: Pigs were subjected to stepwise mesenteric blood flow reduction (15% in each step, n = 8) or served as controls (n = 5). Superior mesenteric arterial blood flow was measured with ultrasonic transit time flowmetry, and mucosal and muscularis microcirculatory perfusion in the small bowel were each measured with three laser Doppler flow probes. Small-bowel intramucosal Pco2 was measured by tonometry, and glucose, lactate (L), and pyruvate (P) were measured by microdialysis. MEASUREMENTS AND MAIN RESULTS: In control animals, superior mesenteric arterial blood flow, mucosal microcirculatory blood flow, intramucosal Pco2, and the lactate/pyruvate ratio remained unchanged. In both groups, mucosal blood flow was better preserved than muscularis blood flow. During stepwise mesenteric blood flow reduction, heterogeneous microcirculatory blood flow remained a prominent feature (coefficient of variation, approximately 45%). A 30% flow reduction from baseline was associated with a decrease in microdialysis glucose concentration from 2.37 (2.10-2.70) mmol/L to 0.57 (0.22-1.60) mmol/L (p < .05). After 75% flow reduction, the microdialysis lactate/pyruvate ratio increased from 8.6 (8.0-14.1) to 27.6 (15.5-37.4, p < .05), and arterial-intramucosal Pco2 gradients increased from 1.3 (0.4-3.5) kPa to 10.8 (8.0-16.0) kPa (p < .05). CONCLUSIONS: Blood flow redistribution and heterogeneous microcirculatory perfusion can explain apparently maintained regional oxidative metabolism during mesenteric hypoperfusion, despite local signs of anaerobic metabolism. Early decreasing glucose concentrations suggest that substrate supply may become crucial before oxygen consumption decreases.
Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links
http://dx.doi.org/10.1097/01.CCM.0000233855.34344.29
ae974a485f413a2113503eed53cd6c53
10.1097/01.CCM.0000233855.34344.29
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Increased blood flow prevents intramucosal acidosis in sheep endotoxemia: a controlled study.
  • Authors: Dubin A, Murias G, Maskin B, Pozo MO, Sottile JP, Barán M, Edul VS, Canales HS, Badie JC, Etcheverry G, Estenssoro E
  • Issue date: 2005 Apr
  • Local metabolic effects of dopexamine on the intestine during mesenteric hypoperfusion.
  • Authors: Fröjse R, Lehtipalo S, Bergstrand U, Biber B, Winsö O, Johansson G, Arnerlöv C
  • Issue date: 2004 Mar
  • Negative mesenteric effects of lung recruitment maneuvers in oleic acid lung injury are transient and short lasting.
  • Authors: Claesson J, Lehtipalo S, Bergstrand U, Arnerlöv C, Winsö O
  • Issue date: 2007 Jan
  • Gut luminal lactate release during gradual intestinal ischemia.
  • Authors: Tenhunen JJ, Jakob SM, Takala JA
  • Issue date: 2001 Dec
  • Intraluminal measurement of enteric mucosal perfusion: relationship to superior mesenteric artery flow during basal and postprandial states in the dog.
  • Authors: Larson MV, Ahlquist DA, Karlstrom L, Sarr MG
  • Issue date: 1994 Jan

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.