Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Thrainsdottir, SMalik, R A
Rosén, I
Jakobsson, F
Bakhtadze, E
Petersson, J
Sundkvist, G
Dahlin, L B
Issue Date
2009-07-01
Metadata
Show full item recordCitation
Acta Neurol. Scand. 2009, 120(1):38-46Abstract
OBJECTIVE: Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. METHODS: Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative perception thresholds were estimated at baseline and follow-up (7-10 years later). RESULTS: Subjects with low MNFD (< or = 4700 fibers/mm(2)) showed decline of peroneal amplitude (P < 0.02) and conduction velocity (P < 0.04), as well as median nerve sensory amplitude (P < 0.05) and motor conduction velocity (P < 0.04) from baseline to follow-up. In linear regression analyses, diabetes influenced decline of nerve conduction. MNFD correlated negatively with body mass index (r = -0.469; P < 0.02). CONCLUSION: Low MNFD may predict progression of neurophysiological dysfunction and links obesity to myelinated nerve fiber loss.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAdditional Links
http://dx.doi.org/10.1111/j.1600-0404.2008.01118.xae974a485f413a2113503eed53cd6c53
10.1111/j.1600-0404.2008.01118.x
Scopus Count
Collections
Related articles
- Pulse pressure is independently associated with sensorimotor peripheral neuropathy in patients with type 2 diabetes.
- Authors: Jarmuzewska EA, Mangoni AA
- Issue date: 2005 Jul
- Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance.
- Authors: Sundkvist G, Dahlin LB, Nilsson H, Eriksson KF, Lindgärde F, Rosén I, Lattimer SA, Sima AA, Sullivan K, Greene DA
- Issue date: 2000 Apr
- A comparison of sural nerve conduction studies in patients with impaired oral glucose tolerance test.
- Authors: Koçer A, Domaç FM, Boylu E, Us O, Tanridağ T
- Issue date: 2007 Dec
- The relationship between sural nerve morphometric findings and measures of peripheral nerve function in mild diabetic neuropathy.
- Authors: Veves A, Malik RA, Lye RH, Masson EA, Sharma AK, Schady W, Boulton AJ
- Issue date: 1991 Dec
- Early peripheral nerve abnormalities in impaired glucose tolerance.
- Authors: Cappellari A, Airaghi L, Capra R, Ciammola A, Branchi A, Levi Minzi G, Bresolin N
- Issue date: 2005 Jun