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Sural nerve biopsy may predict future nerve dysfunction

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Authors
Thrainsdottir, S
Malik, R A
Rosén, I
Jakobsson, F
Bakhtadze, E
Petersson, J
Sundkvist, G
Dahlin, L B
Issue Date
2009-07-01

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Citation
Acta Neurol. Scand. 2009, 120(1):38-46
Abstract
OBJECTIVE: Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. METHODS: Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative perception thresholds were estimated at baseline and follow-up (7-10 years later). RESULTS: Subjects with low MNFD (< or = 4700 fibers/mm(2)) showed decline of peroneal amplitude (P < 0.02) and conduction velocity (P < 0.04), as well as median nerve sensory amplitude (P < 0.05) and motor conduction velocity (P < 0.04) from baseline to follow-up. In linear regression analyses, diabetes influenced decline of nerve conduction. MNFD correlated negatively with body mass index (r = -0.469; P < 0.02). CONCLUSION: Low MNFD may predict progression of neurophysiological dysfunction and links obesity to myelinated nerve fiber loss.
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http://dx.doi.org/10.1111/j.1600-0404.2008.01118.x
ae974a485f413a2113503eed53cd6c53
10.1111/j.1600-0404.2008.01118.x
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