Sural nerve biopsy may predict future nerve dysfunction
| dc.contributor.author | Thrainsdottir, S | |
| dc.contributor.author | Malik, R A | |
| dc.contributor.author | Rosén, I | |
| dc.contributor.author | Jakobsson, F | |
| dc.contributor.author | Bakhtadze, E | |
| dc.contributor.author | Petersson, J | |
| dc.contributor.author | Sundkvist, G | |
| dc.contributor.author | Dahlin, L B | |
| dc.date.accessioned | 2009-07-13T15:53:09Z | |
| dc.date.available | 2009-07-13T15:53:09Z | |
| dc.date.issued | 2009-07-01 | |
| dc.date.submitted | 2009-07-13 | |
| dc.identifier.citation | Acta Neurol. Scand. 2009, 120(1):38-46 | en |
| dc.identifier.issn | 1600-0404 | |
| dc.identifier.pmid | 19154542 | |
| dc.identifier.doi | 10.1111/j.1600-0404.2008.01118.x | |
| dc.identifier.uri | http://hdl.handle.net/2336/73573 | |
| dc.description | To access publisher full text version of this article. Please click on the hyperlink in Additional Links field | en |
| dc.description.abstract | OBJECTIVE: Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. METHODS: Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative perception thresholds were estimated at baseline and follow-up (7-10 years later). RESULTS: Subjects with low MNFD (< or = 4700 fibers/mm(2)) showed decline of peroneal amplitude (P < 0.02) and conduction velocity (P < 0.04), as well as median nerve sensory amplitude (P < 0.05) and motor conduction velocity (P < 0.04) from baseline to follow-up. In linear regression analyses, diabetes influenced decline of nerve conduction. MNFD correlated negatively with body mass index (r = -0.469; P < 0.02). CONCLUSION: Low MNFD may predict progression of neurophysiological dysfunction and links obesity to myelinated nerve fiber loss. | |
| dc.language.iso | en | en |
| dc.publisher | Wiley-Blackwell | en |
| dc.relation.url | http://dx.doi.org/10.1111/j.1600-0404.2008.01118.x | en |
| dc.subject.mesh | Diabetes Mellitus, Type 2 | en |
| dc.subject.mesh | Body Mass Index | en |
| dc.title | Sural nerve biopsy may predict future nerve dysfunction | en |
| dc.type | Article | en |
| dc.contributor.department | Department of Clinical Sciences and Neurology, Lund University, Lund, Sweden. soleyth@landspitali.is | en |
| dc.identifier.journal | Acta neurologica Scandinavica | en |
| html.description.abstract | OBJECTIVE: Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. METHODS: Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative perception thresholds were estimated at baseline and follow-up (7-10 years later). RESULTS: Subjects with low MNFD (< or = 4700 fibers/mm(2)) showed decline of peroneal amplitude (P < 0.02) and conduction velocity (P < 0.04), as well as median nerve sensory amplitude (P < 0.05) and motor conduction velocity (P < 0.04) from baseline to follow-up. In linear regression analyses, diabetes influenced decline of nerve conduction. MNFD correlated negatively with body mass index (r = -0.469; P < 0.02). CONCLUSION: Low MNFD may predict progression of neurophysiological dysfunction and links obesity to myelinated nerve fiber loss. |