Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsWelt, C K
Gudmundsson, J A
Crowley, W F
MetadataShow full item record
CitationJ. Clin. Endocrinol. Metab. 2006, 91(12):4842-8
AbstractCONTEXT: The Rotterdam criteria for polycystic ovary syndrome (PCOS) defines discrete subgroups whose phenotypes are not yet clear. OBJECTIVE: The phenotypic characteristics of women in the PCOS subgroups defined by the Rotterdam criteria were compared. DESIGN: The study was observational. SETTING: Subjects were studied in an outpatient setting in Boston and Reykjavik. PATIENTS: Four subgroups of subjects with PCOS defined by 1) irregular menses (IM), hyperandrogenism (HA), and polycystic ovary morphology (PCOM, n = 298); 2) IM/HA (n = 7); 3) HA/PCOM (n = 77); and 4) IM/PCOM (n = 36) and a group of controls (n = 64), aged 18-45 yr, were examined. INTERVENTION: Subjects underwent a physical exam; fasting blood samples for androgens, gonadotropins, and metabolic parameters; and a transvaginal ultrasound. MAIN OUTCOME MEASURES: The phenotype was compared between groups. RESULTS: Ninety-seven percent of women with IM/HA had PCOM. Therefore, the groups with and without PCOM were combined. The Ferriman-Gallwey score and androgen levels were highest in the hyperandrogenic groups (IM/HA and HA/PCOM), whereas ovarian volume was higher in all PCOS subgroups compared with controls, as expected based on the definitions of the PCOS subgroups. Body mass index and insulin levels were highest in the IM/HA subgroup. CONCLUSIONS: Subjects with PCOS defined by IM/HA are the most severely affected women on the basis of androgen levels, ovarian volumes, and insulin levels. Their higher body mass index partially accounts for the increased insulin levels, suggesting that weight gain exacerbates the symptoms of PCOS.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Defining constant versus variable phenotypic features of women with polycystic ovary syndrome using different ethnic groups and populations.
- Authors: Welt CK, Arason G, Gudmundsson JA, Adams J, Palsdóttir H, Gudlaugsdóttir G, Ingadóttir G, Crowley WF
- Issue date: 2006 Nov
- Polycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotype.
- Authors: Legro RS, Chiu P, Kunselman AR, Bentley CM, Dodson WC, Dunaif A
- Issue date: 2005 May
- Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women.
- Authors: Chae SJ, Kim JJ, Choi YM, Hwang KR, Jee BC, Ku SY, Suh CS, Kim SH, Kim JG, Moon SY
- Issue date: 2008 Aug
- The complex relationship between hypothalamic amenorrhea and polycystic ovary syndrome.
- Authors: Wang JG, Lobo RA
- Issue date: 2008 Apr
- Use of the serum anti-Müllerian hormone assay as a surrogate for polycystic ovarian morphology: impact on diagnosis and phenotypic classification of polycystic ovary syndrome.
- Authors: Fraissinet A, Robin G, Pigny P, Lefebvre T, Catteau-Jonard S, Dewailly D
- Issue date: 2017 Aug 1