Neutrophil CD64 as a marker for postoperative infection: a pilot study.
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CitationEur J Vasc Endovasc Surg. 2009, 38(1):100-3
AbstractThe aim of this pilot study was to evaluate the clinical utility of quantitative CD64 measurements to differentiate between systemic inflammation in response to surgical trauma and postoperative bacterial infection. In a consecutive series of 153 patients undergoing elective vascular surgery, peripheral venous blood samples were taken preoperatively on admission and postoperatively during the first 24h. The samples were analysed for C-reactive protein (CRP), total leucocyte counts (white blood cell (WBC)), serum procalcitonin (PCT) and neutrophil CD64 expression. Of the 153 patients, the focus is on those with (1) postoperative infection alone (group 1; n=1 4); (2) pre- and postoperative infection (group 2; n=6); and (3) postoperative fever with no other signs of infection (group 3; n=29). In group 1, all four markers were significantly increased in the 24h after surgery: CD64 (p=0.001), CRP (p=0.001), WBC (p=0.002) and PCT (p=0.012); in group 2, there was no significant difference in the CD64 (p=0.116), WBC (p=0.249) and PCT (p=0.138) values, whereas a marginal significance was shown for CRP (p=0.046); and the results for group 3 were similar to those of group 1. This pilot study suggests that the role of neutrophil CD64 measurements in facilitating the diagnosis of early postoperative infection merits further investigation.
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- Detection of acute phase response and infection. The role of procalcitonin and C-reactive protein.
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- Issue date: 1999 Mar
- Neutrophil CD64 as a Marker of Bacterial Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease.
- Authors: Qian W, Huang GZ
- Issue date: 2016 Aug
- [Value of combined determination of neutrophil CD64 and procalcitonin in early diagnosis of neonatal bacterial infection].
- Authors: Qin DJ, Tang ZS, Chen SL, Xu XM, Mao SG, Zhang SF
- Issue date: 2017 Aug
- Usefulness of procalcitonin for diagnosis of infection in cardiac surgical patients.
- Authors: Aouifi A, Piriou V, Bastien O, Blanc P, Bouvier H, Evans R, Célard M, Vandenesch F, Rousson R, Lehot JJ
- Issue date: 2000 Sep
- [Procalcitonin plasma concentrations and systemic inflammatory response following different types of surgery].
- Authors: Molter GP, Soltész S, Kottke R, Wilhelm W, Biedler A, Silomon M
- Issue date: 2003 Mar