Neutrophil CD64 as a marker for postoperative infection: a pilot study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationEur J Vasc Endovasc Surg. 2009, 38(1):100-3
ÚtdrátturThe aim of this pilot study was to evaluate the clinical utility of quantitative CD64 measurements to differentiate between systemic inflammation in response to surgical trauma and postoperative bacterial infection. In a consecutive series of 153 patients undergoing elective vascular surgery, peripheral venous blood samples were taken preoperatively on admission and postoperatively during the first 24h. The samples were analysed for C-reactive protein (CRP), total leucocyte counts (white blood cell (WBC)), serum procalcitonin (PCT) and neutrophil CD64 expression. Of the 153 patients, the focus is on those with (1) postoperative infection alone (group 1; n=1 4); (2) pre- and postoperative infection (group 2; n=6); and (3) postoperative fever with no other signs of infection (group 3; n=29). In group 1, all four markers were significantly increased in the 24h after surgery: CD64 (p=0.001), CRP (p=0.001), WBC (p=0.002) and PCT (p=0.012); in group 2, there was no significant difference in the CD64 (p=0.116), WBC (p=0.249) and PCT (p=0.138) values, whereas a marginal significance was shown for CRP (p=0.046); and the results for group 3 were similar to those of group 1. This pilot study suggests that the role of neutrophil CD64 measurements in facilitating the diagnosis of early postoperative infection merits further investigation.
Lu00FDsingTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Detection of acute phase response and infection. The role of procalcitonin and C-reactive protein.
- Authors: Rothenburger M, Markewitz A, Lenz T, Kaulbach HG, Marohl K, Kuhlmann WD, Weinhold C
- Issue date: 1999 Mar
- Neutrophil CD64 as a Marker of Bacterial Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease.
- Authors: Qian W, Huang GZ
- Issue date: 2016 Aug
- [Procalcitonin plasma concentrations and systemic inflammatory response following different types of surgery].
- Authors: Molter GP, Soltész S, Kottke R, Wilhelm W, Biedler A, Silomon M
- Issue date: 2003 Mar
- Neutrophil CD64, C-reactive protein, and procalcitonin in the identification of sepsis in the ICU - Post-test probabilities.
- Authors: Jämsä J, Ala-Kokko T, Huotari V, Ohtonen P, Savolainen ER, Syrjälä H
- Issue date: 2018 Feb
- The usefulness of neutrophil CD64 expression for diagnosing infection after orthopaedic surgery in dialysis patients.
- Authors: Doi T, Doi T, Kawamura N, Matsui T, Komiya A, Tei Z, Niitsuma G, Kunogi J
- Issue date: 2016 Jul