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dc.contributor.authorDaryapeyma, A
dc.contributor.authorPedersen, G
dc.contributor.authorLaxdal, E
dc.contributor.authorCorbascio, M
dc.contributor.authorJohannessen, H B
dc.contributor.authorAune, S
dc.contributor.authorJonung, T
dc.date.accessioned2009-08-05T09:44:34Z
dc.date.available2009-08-05T09:44:34Z
dc.date.issued2009-07-01
dc.date.submitted2009-08-05
dc.identifier.citationEur J Vasc Endovasc Surg. 2009, 38(1):100-3en
dc.identifier.issn1532-2165
dc.identifier.pmid19359198
dc.identifier.doi10.1016/j.ejvs.2009.03.012
dc.identifier.urihttp://hdl.handle.net/2336/76322
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThe aim of this pilot study was to evaluate the clinical utility of quantitative CD64 measurements to differentiate between systemic inflammation in response to surgical trauma and postoperative bacterial infection. In a consecutive series of 153 patients undergoing elective vascular surgery, peripheral venous blood samples were taken preoperatively on admission and postoperatively during the first 24h. The samples were analysed for C-reactive protein (CRP), total leucocyte counts (white blood cell (WBC)), serum procalcitonin (PCT) and neutrophil CD64 expression. Of the 153 patients, the focus is on those with (1) postoperative infection alone (group 1; n=1 4); (2) pre- and postoperative infection (group 2; n=6); and (3) postoperative fever with no other signs of infection (group 3; n=29). In group 1, all four markers were significantly increased in the 24h after surgery: CD64 (p=0.001), CRP (p=0.001), WBC (p=0.002) and PCT (p=0.012); in group 2, there was no significant difference in the CD64 (p=0.116), WBC (p=0.249) and PCT (p=0.138) values, whereas a marginal significance was shown for CRP (p=0.046); and the results for group 3 were similar to those of group 1. This pilot study suggests that the role of neutrophil CD64 measurements in facilitating the diagnosis of early postoperative infection merits further investigation.
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://dx.doi.org/10.1016/j.ejvs.2009.03.012en
dc.subject.meshBiological Markersen
dc.subject.meshC-Reactive Proteinen
dc.subject.meshCalcitoninen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshGlycoproteinsen
dc.subject.meshHumansen
dc.subject.meshLeukocyte Counten
dc.subject.meshNeutrophilsen
dc.subject.meshPilot Projectsen
dc.subject.meshProtein Precursorsen
dc.subject.meshReceptors, IgGen
dc.subject.meshSensitivity and Specificityen
dc.subject.meshSurgical Wound Infectionen
dc.subject.meshVascular Surgical Proceduresen
dc.titleNeutrophil CD64 as a marker for postoperative infection: a pilot study.en
dc.typeArticleen
dc.contributor.departmentSurgical Clinic, Haukeland University Hospital, Bergen, Norway. alireza.daryapeyma@helse-bergen.noen
dc.identifier.journalEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgeryen
html.description.abstractThe aim of this pilot study was to evaluate the clinical utility of quantitative CD64 measurements to differentiate between systemic inflammation in response to surgical trauma and postoperative bacterial infection. In a consecutive series of 153 patients undergoing elective vascular surgery, peripheral venous blood samples were taken preoperatively on admission and postoperatively during the first 24h. The samples were analysed for C-reactive protein (CRP), total leucocyte counts (white blood cell (WBC)), serum procalcitonin (PCT) and neutrophil CD64 expression. Of the 153 patients, the focus is on those with (1) postoperative infection alone (group 1; n=1 4); (2) pre- and postoperative infection (group 2; n=6); and (3) postoperative fever with no other signs of infection (group 3; n=29). In group 1, all four markers were significantly increased in the 24h after surgery: CD64 (p=0.001), CRP (p=0.001), WBC (p=0.002) and PCT (p=0.012); in group 2, there was no significant difference in the CD64 (p=0.116), WBC (p=0.249) and PCT (p=0.138) values, whereas a marginal significance was shown for CRP (p=0.046); and the results for group 3 were similar to those of group 1. This pilot study suggests that the role of neutrophil CD64 measurements in facilitating the diagnosis of early postoperative infection merits further investigation.


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