HLA-B8, DR3: a new risk factor for graft failure after renal transplantation in patients with underlying immunoglobulin A nephropathy
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationClin Transplant 2009, 23(5):660-5
AbstractBACKGROUND: The HLA-B8, DR3 haplotype has been associated with high immune reactivity. In this study, we have tested whether this haplotype has differential effect on graft survival in patients with IgAN compared with control patients. METHODS: From the Eurotransplant Registry we analyzed graft survival of 1207 recipients with IgAN and 7935 control patients with non-glomerular diseases. Death-censored graft loss according to the HLA-B8, DR3 haplotype was calculated with Kaplan-Meier analysis and Cox-regression model was used to correct for various risk factors. RESULTS: The frequency of the HLA-B8, DR3 haplotype was significantly lower in IgAN patients compared with controls (10.3% vs. 15.4%, p < 0.001). Ten-year graft survival was identical in the control group with and without the HLA-B8, DR3 haplotype (71.1% and 70.2%, respectively), but significantly worse in IgAN patients carrying the HLA-B8, DR3 haplotype compared with patients without it (52.5% vs. 69.1%, respectively, p = 0.009). The risk of graft loss was increased by 66% (HR 1.6, 95% CI 1.14, 2.29) in IgAN with the HLA-B8, DR3 haplotype and independent of well-known risk factors. CONCLUSIONS: We have identified a new risk factor for graft loss unique to patients with IgAN. This finding emphasizes the exclusive immune characteristics of IgAN patients after transplantation.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Exclusive characteristics of graft survival and risk factors in recipients with immunoglobulin A nephropathy: a retrospective analysis of registry data.
- Authors: Andresdottir MB, Haasnoot GW, Doxiadis II, Persijn GG, Claas FH
- Issue date: 2005 Oct 27
- Favorable outcome of renal transplantation in patients with IgA nephropathy.
- Authors: Andresdottir MB, Hoitsma AJ, Assmann KJ, Wetzels JF
- Issue date: 2001 Oct
- Megsin 2093T-2180C haplotype at the 3' untranslated region is associated with poor renal survival in Korean IgA nephropathy patients.
- Authors: Lim CS, Kim SM, Oh YK, Joo KW, Kim YS, Han JS, Kim S
- Issue date: 2008 Aug
- Human leukocyte antigen-B8-DR3 is a more important risk factor for severe Puumala hantavirus infection than the tumor necrosis factor-alpha(-308) G/A polymorphism.
- Authors: Mäkelä S, Mustonen J, Ala-Houhala I, Hurme M, Partanen J, Vapalahti O, Vaheri A, Pasternack A
- Issue date: 2002 Sep 15
- Central MHC genes affect IgA levels in the human: reciprocal effects in IgA deficiency and IgA nephropathy.
- Authors: Matthews VB, Witt CS, French MA, Machulla HK, De la Concha EG, Cheong KY, Vigil P, Hollingsworth PN, Warr KJ, Christiansen FT, Price P
- Issue date: 2002 May