HLA-B8, DR3: a new risk factor for graft failure after renal transplantation in patients with underlying immunoglobulin A nephropathy
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Issue Date
2009-10-01
Metadata
Show full item recordCitation
Clin Transplant 2009, 23(5):660-5Abstract
BACKGROUND: The HLA-B8, DR3 haplotype has been associated with high immune reactivity. In this study, we have tested whether this haplotype has differential effect on graft survival in patients with IgAN compared with control patients. METHODS: From the Eurotransplant Registry we analyzed graft survival of 1207 recipients with IgAN and 7935 control patients with non-glomerular diseases. Death-censored graft loss according to the HLA-B8, DR3 haplotype was calculated with Kaplan-Meier analysis and Cox-regression model was used to correct for various risk factors. RESULTS: The frequency of the HLA-B8, DR3 haplotype was significantly lower in IgAN patients compared with controls (10.3% vs. 15.4%, p < 0.001). Ten-year graft survival was identical in the control group with and without the HLA-B8, DR3 haplotype (71.1% and 70.2%, respectively), but significantly worse in IgAN patients carrying the HLA-B8, DR3 haplotype compared with patients without it (52.5% vs. 69.1%, respectively, p = 0.009). The risk of graft loss was increased by 66% (HR 1.6, 95% CI 1.14, 2.29) in IgAN with the HLA-B8, DR3 haplotype and independent of well-known risk factors. CONCLUSIONS: We have identified a new risk factor for graft loss unique to patients with IgAN. This finding emphasizes the exclusive immune characteristics of IgAN patients after transplantation.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAdditional Links
http://dx.doi.org/10.1111/j.1399-0012.2009.01059.xae974a485f413a2113503eed53cd6c53
10.1111/j.1399-0012.2009.01059.x
Scopus Count
Collections
Related articles
- Favorable outcome of renal transplantation in patients with IgA nephropathy.
- Authors: Andresdottir MB, Hoitsma AJ, Assmann KJ, Wetzels JF
- Issue date: 2001 Oct
- Human leukocyte antigen-B8-DR3 is a more important risk factor for severe Puumala hantavirus infection than the tumor necrosis factor-alpha(-308) G/A polymorphism.
- Authors: Mäkelä S, Mustonen J, Ala-Houhala I, Hurme M, Partanen J, Vapalahti O, Vaheri A, Pasternack A
- Issue date: 2002 Sep 15
- Latent IgA deposition from donor kidney is the major risk factor for recurrent IgA nephropathy in renal transplantation.
- Authors: Moriyama T, Nitta K, Suzuki K, Honda K, Horita S, Uchida K, Yumura W, Tanabe K, Toma H, Nihei H, Yamaguchi Y
- Issue date: 2005
- Impact of human leukocyte antigen matching and recipients' panel reactive antibodies on two-year outcome in presensitized renal allograft recipients.
- Authors: Meng HL, Jin XB, Li XT, Wang HW, Lü JJ
- Issue date: 2009 Feb 20
- Recurrence of IgA nephropathy among renal allograft recipients from living donors is greater among those with zero HLA mismatches.
- Authors: McDonald SP, Russ GR
- Issue date: 2006 Sep 27