A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
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Authors
Gudbjartsson, Daniel FHolm, Hilma
Gretarsdottir, Solveig
Thorleifsson, Gudmar
Walters, G Bragi
Thorgeirsson, Gudmundur
Gulcher, Jeffrey
Mathiesen, Ellisiv B
Njølstad, Inger
Nyrnes, Audhild
Wilsgaard, Tom
Hald, Erin M
Hveem, Kristian
Stoltenberg, Camilla
Kucera, Gayle
Stubblefield, Tanya
Carter, Shannon
Roden, Dan
Ng, Maggie C Y
Baum, Larry
So, Wing Yee
Wong, Ka Sing
Chan, Juliana C N
Gieger, Christian
Wichmann, H-Erich
Gschwendtner, Andreas
Dichgans, Martin
Kuhlenbäumer, Gregor
Berger, Klaus
Ringelstein, E Bernd
Bevan, Steve
Markus, Hugh S
Kostulas, Konstantinos
Hillert, Jan
Sveinbjörnsdóttir, Sigurlaug
Valdimarsson, Einar M
Løchen, Maja-Lisa
Ma, Ronald C W
Darbar, Dawood
Kong, Augustine
Arnar, David O
Thorsteinsdottir, Unnur
Stefansson, Kari
Issue Date
2009-08-01
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Nat. Genet. 2009, 41(8):876-8Abstract
We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.Description
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/OpenAdditional Links
http://dx.doi.org/10.1038/ng.417ae974a485f413a2113503eed53cd6c53
10.1038/ng.417
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