A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.

Gudbjartsson, Daniel F; Holm, Hilma; Gretarsdottir, Solveig; Thorleifsson, Gudmar; Walters, G Bragi; Thorgeirsson, Gudmundur; Gulcher, Jeffrey; Mathiesen, Ellisiv B; Njølstad, Inger; Nyrnes, Audhild; Wilsgaard, Tom; Hald, Erin M; Hveem, Kristian; Stoltenberg, Camilla; Kucera, Gayle; Stubblefield, Tanya; Carter, Shannon; Roden, Dan; Ng, Maggie C Y; Baum, Larry; So, Wing Yee; Wong, Ka Sing; Chan, Juliana C N; Gieger, Christian; Wichmann, H-Erich; Gschwendtner, Andreas; Dichgans, Martin; Kuhlenbäumer, Gregor; Berger, Klaus; Ringelstein, E Bernd; Bevan, Steve; Markus, Hugh S; Kostulas, Konstantinos; Hillert, Jan; Sveinbjörnsdóttir, Sigurlaug; Valdimarsson, Einar M; Løchen, Maja-Lisa; Ma, Ronald C W; Darbar, Dawood; Kong, Augustine; Arnar, David O; Thorsteinsdottir, Unnur; Stefansson, Kari

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Issue Date

2009-08-01

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Citation

Nat. Genet. 2009, 41(8):876-8

Abstract

We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.

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Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open

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http://dx.doi.org/10.1038/ng.417

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English Journal Articles (Peer Reviewed)