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dc.contributor.authorGudbjartsson, Daniel F
dc.contributor.authorHolm, Hilma
dc.contributor.authorGretarsdottir, Solveig
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorWalters, G Bragi
dc.contributor.authorThorgeirsson, Gudmundur
dc.contributor.authorGulcher, Jeffrey
dc.contributor.authorMathiesen, Ellisiv B
dc.contributor.authorNjølstad, Inger
dc.contributor.authorNyrnes, Audhild
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorHald, Erin M
dc.contributor.authorHveem, Kristian
dc.contributor.authorStoltenberg, Camilla
dc.contributor.authorKucera, Gayle
dc.contributor.authorStubblefield, Tanya
dc.contributor.authorCarter, Shannon
dc.contributor.authorRoden, Dan
dc.contributor.authorNg, Maggie C Y
dc.contributor.authorBaum, Larry
dc.contributor.authorSo, Wing Yee
dc.contributor.authorWong, Ka Sing
dc.contributor.authorChan, Juliana C N
dc.contributor.authorGieger, Christian
dc.contributor.authorWichmann, H-Erich
dc.contributor.authorGschwendtner, Andreas
dc.contributor.authorDichgans, Martin
dc.contributor.authorKuhlenbäumer, Gregor
dc.contributor.authorBerger, Klaus
dc.contributor.authorRingelstein, E Bernd
dc.contributor.authorBevan, Steve
dc.contributor.authorMarkus, Hugh S
dc.contributor.authorKostulas, Konstantinos
dc.contributor.authorHillert, Jan
dc.contributor.authorSveinbjörnsdóttir, Sigurlaug
dc.contributor.authorValdimarsson, Einar M
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorMa, Ronald C W
dc.contributor.authorDarbar, Dawood
dc.contributor.authorKong, Augustine
dc.contributor.authorArnar, David O
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorStefansson, Kari
dc.date.accessioned2009-10-23T14:23:48Z
dc.date.available2009-10-23T14:23:48Z
dc.date.issued2009-08-01
dc.date.submitted2009-10-23
dc.identifier.citationNat. Genet. 2009, 41(8):876-8en
dc.identifier.issn1546-1718
dc.identifier.pmid19597491
dc.identifier.doi10.1038/ng.417
dc.identifier.urihttp://hdl.handle.net/2336/84801
dc.descriptionNeðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Openen
dc.description.abstractWe expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1038/ng.417en
dc.subject.meshAtrial Fibrillationen
dc.subject.meshBase Sequenceen
dc.subject.meshBrain Ischemiaen
dc.subject.meshChromosomes, Human, Pair 16en
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHomeodomain Proteinsen
dc.subject.meshHumansen
dc.subject.meshMutationen
dc.subject.meshStrokeen
dc.titleA sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.en
dc.typeArticleen
dc.contributor.departmentDeCode Genetics, Reykjavik, Iceland. daniel.gudbjartsson@decode.isen
dc.identifier.journalNature geneticsen
html.description.abstractWe expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.


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