Hand osteoarthritis in older women is associated with carotid and coronary atherosclerosis: the AGES Reykjavik study
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Jonsson, HHelgadottir, G P
Aspelund, T
Eiriksdottir, G
Sigurdsson, S
Ingvarsson, T
Harris, T B
Launer, L
Gudnason, V
Issue Date
2009-11-01
Metadata
Show full item recordCitation
Ann. Rheum. Dis. 2009, 68(11):1696-700Abstract
OBJECTIVE: There is evidence that atherosclerosis may contribute to the initiation or progression of osteoarthritis. To test this hypothesis, the presence and severity of hand osteoarthritis (HOA) was compared with markers of atherosclerotic vascular disease in an elderly population. Patients and METHODS: The AGES Reykjavik Study is a population-based multidisciplinary study of ageing in the elderly population of Reykjavik. In a study of 2264 men (mean age 76 years; SD 6) and 3078 women (mean age 76 years; SD 6) the severity of HOA, scored from photographs, was compared with measures of atherosclerosis. These included carotid intimal thickness and plaque severity, coronary calcifications (CAC) and aortic calcifications and reported cardiac and cerebrovascular events. RESULTS: After adjustment for confounders, both carotid plaque severity and CAC were significantly associated with HOA in women, with an odds ratio of 1.42 (95% CI 1.14 to 1.76, p = 0.002) for having CAC and 1.25 (95% CI 1.04 to 1.49, p = 0.016) for having moderate or severe carotid plaques. Both carotid plaques and CAC also exhibited significant linear trends in relation to HOA severity in women in the whole AGES Reykjavik cohort (p<0.001 and p = 0.027, respectively, for trend). No significant associations were seen in men. Despite this evidence of increased atherosclerosis, women with HOA did not report proportionally more previous cardiovascular or cerebrovascular events. CONCLUSIONS: The results indicate a linear association between the severity of HOA and atherosclerosis in older women. The pathological process of HOA seems to have some components in common with atherosclerosis. Prospective studies may help elucidate the possible mechanisms of this relationship.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAdditional Links
http://dx.doi.org/10.1136/ard.2008.096289ae974a485f413a2113503eed53cd6c53
10.1136/ard.2008.096289
Scopus Count
Collections
Related articles
- The presence of total knee or hip replacements due to osteoarthritis enhances the positive association between hand osteoarthritis and atherosclerosis in women: the AGES-Reykjavik study.
- Authors: Jonsson H, Helgadottir GP, Aspelund T, Eiriksdottir G, Sigurdsson S, Siggeirsdottir K, Ingvarsson T, Harris TB, Launer L, Gudnason V
- Issue date: 2011 Jun
- Population distribution of traditional and the emerging cardiovascular risk factors carotid plaque and IMT: the REFINE-Reykjavik study with comparison with the Tromsø study.
- Authors: Thorsson B, Eiriksdottir G, Sigurdsson S, Gudmundsson EF, Bots ML, Aspelund T, Arntzen KA, Mathiesen EB, Gudnason V
- Issue date: 2018 May 31
- Racial differences in the association between carotid plaque and aortic and coronary artery calcification among women transitioning through menopause.
- Authors: Woodard GA, Narla VV, Ye R, Cauley JA, Thompson T, Matthews KA, Sutton-Tyrrell K
- Issue date: 2012 Feb
- Age related prevalence of hand osteoarthritis diagnosed by photography (HOASCORE).
- Authors: Jonsson H
- Issue date: 2017 Dec 2
- The use of digital photographs for the diagnosis of hand osteoarthritis: the AGES-Reykjavik study.
- Authors: Jonsson H, Helgadottir GP, Aspelund T, Sverrisdottir JE, Eiriksdottir G, Sigurdsson S, Eliasson GJ, Jonsson A, Ingvarsson T, Harris TB, Launer L, Gudnason V
- Issue date: 2012 Feb 16