Accumulation of coronary artery disease risk factors over three years: data from an international inception cohort.
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Authors
Urowitz, M BGladman, D
Ibañez, D
Fortin, P
Sanchez-Guerrero, J
Bae, S
Clarke, A
Bernatsky, S
Gordon, C
Hanly, J
Wallace, D
Isenberg, D
Ginzler, E
Merrill, J
Alarcón, G S
Steinsson, K
Petri, M
Dooley, M A
Bruce, I
Manzi, S
Khamashta, M
Ramsey-Goldman, R
Zoma, A
Sturfelt, G
Nived, O
Maddison, P
Font, J
van Vollenhoven, R
Aranow, C
Kalunian, K
Stoll, T
Issue Date
2008-02-15
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Arthritis Rheum. 2008, 59(2):176-80Abstract
OBJECTIVE: To examine the accumulation of risk factors over 3 years in a multicenter, international inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: The Systemic Lupus International Collaborating Clinics registry for atherosclerosis comprises 27 centers from 11 countries. An inception cohort of 935 patients with SLE was assembled, according to a standardized protocol, from 2000 to 2006 to study risk factors for atherosclerosis. Both classic and other coronary artery disease (CAD) risk factors were collected at entry and through 3 years of followup. Therapy was documented over the 3 years. The Framingham 10-year risk factor profile was calculated for each patient at year 1 and year 3. RESULTS: A total of 278 patients from the inception cohort were followed for 3 years and constituted the population for this study. At enrollment a substantial number of patients already demonstrated several risk factors for CAD, both classic and other. All risk factors increased from enrollment over the 3 years of followup. Treatment of hypertension and hypercholesterolemia also increased over 3 years, but less so for hypercholesterolemia. The Framingham 10-year CAD risk profile was higher in men than in women both at entry and at 3 years, and remained unchanged over the 3 years. Corticosteroid use increased only slightly over 3 years, but use of antimalarials and immunosuppressive agents increased to a greater extent. CONCLUSION: Patients with SLE should be monitored for CAD risk factors from the time of diagnosis and appropriate treatment should be instituted early.Description
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http://dx.doi.org/10.1002/art.23353ae974a485f413a2113503eed53cd6c53
10.1002/art.23353
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