64,XX, SRY-, and ZFY-negative Icelandic horse likely to be true hermaphrodite
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Issue Date
2009-10-01
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J. Equine Vet. Sci. 2009, 29(10):734-8Abstract
A 4-year-old Icelandic horse, considered to be a mare, showed stallion-like behavior in a group of mares. On clinical examination, the horse turned out to have an enlarged erectable phallic clitoris. Ultrasound examination showed a normal-sized left ovary covered with numerous small follicular cysts and a compact testis-like tissue in place of the right ovary. The karyotype was normal for a mare (64,XX), and the horse was found to be negative for the Y chromosome-specific markers SRY, ZFY, and EIF1AY. This case indicates that the intersexual phenotype may be caused by autosomal recessive mutation, resulting in defects in cortisol biosynthesis rather than transferal of Y chromosome male-specific genes. This is the first report of an intersexual phenotype in an Icelandic horse that is likely to be a true hermaphrodite because of female sex chromosomes and a mixture of female and male gonads and external genitals.Description
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http://dx.doi.org/10.1016/j.jevs.2009.08.007ae974a485f413a2113503eed53cd6c53
10.1016/j.jevs.2009.08.007
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