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dc.contributor.authorBodvarsdottir, S K
dc.contributor.authorImsland, F
dc.contributor.authorThorisson, B
dc.contributor.authorSteinarsdottir, M
dc.contributor.authorEyfjord, J E
dc.date.accessioned2009-11-03T09:40:51Z
dc.date.available2009-11-03T09:40:51Z
dc.date.issued2009-10-01
dc.date.submitted2009-11-03
dc.identifier.citationJ. Equine Vet. Sci. 2009, 29(10):734-8en
dc.identifier.issn07370806
dc.identifier.doi10.1016/j.jevs.2009.08.007
dc.identifier.urihttp://hdl.handle.net/2336/85233
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractA 4-year-old Icelandic horse, considered to be a mare, showed stallion-like behavior in a group of mares. On clinical examination, the horse turned out to have an enlarged erectable phallic clitoris. Ultrasound examination showed a normal-sized left ovary covered with numerous small follicular cysts and a compact testis-like tissue in place of the right ovary. The karyotype was normal for a mare (64,XX), and the horse was found to be negative for the Y chromosome-specific markers SRY, ZFY, and EIF1AY. This case indicates that the intersexual phenotype may be caused by autosomal recessive mutation, resulting in defects in cortisol biosynthesis rather than transferal of Y chromosome male-specific genes. This is the first report of an intersexual phenotype in an Icelandic horse that is likely to be a true hermaphrodite because of female sex chromosomes and a mixture of female and male gonads and external genitals.
dc.language.isoisen
dc.publisherW. B. Saunders Co.en
dc.relation.urlhttp://dx.doi.org/10.1016/j.jevs.2009.08.007en
dc.title64,XX, SRY-, and ZFY-negative Icelandic horse likely to be true hermaphroditeis
dc.typeArticleen
dc.identifier.journalJournal of equine veterinary scienceen
html.description.abstractA 4-year-old Icelandic horse, considered to be a mare, showed stallion-like behavior in a group of mares. On clinical examination, the horse turned out to have an enlarged erectable phallic clitoris. Ultrasound examination showed a normal-sized left ovary covered with numerous small follicular cysts and a compact testis-like tissue in place of the right ovary. The karyotype was normal for a mare (64,XX), and the horse was found to be negative for the Y chromosome-specific markers SRY, ZFY, and EIF1AY. This case indicates that the intersexual phenotype may be caused by autosomal recessive mutation, resulting in defects in cortisol biosynthesis rather than transferal of Y chromosome male-specific genes. This is the first report of an intersexual phenotype in an Icelandic horse that is likely to be a true hermaphrodite because of female sex chromosomes and a mixture of female and male gonads and external genitals.


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