Hypertension, systemic inflammation and body weight in relation to lung function impairment-an epidemiological study
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsMargretardottir, Olof Birna
Thorleifsson, Sigurdur James
Buist, A Sonia
MetadataShow full item record
CitationCOPD. 2009, 6(4):250-5
AbstractRecent reports on the simultaneous occurrence of systemic inflammation and airflow obstruction are usually based on a highly selective patient population, but their importance warrants further evaluation in the general population. The objectives were to study the interrelationship between airflow obstruction, smoking, hypertension, obesity and CRP as a marker of systemic inflammation in a randomly selected sample of the general Icelandic population (n = 939). This study comprised 758 randomly selected men and women 40 years and older living in Reykjavik, Iceland, and who were participating in the Burden of Obstructive Lung Disease (BOLD) study (81% response rate). In addition to the BOLD protocol, which included post-bronchodilator spirometry, they answered questions about general health and medication. Serum samples were taken for measurement of C-reactive protein (CRP). In the sample-245 individuals (33%) reported having hypertension. Subjects with hypertension were older, had a higher BMI and higher CRP levels. Subjects with hypertension had lower values of FEV(1) than predicted (89.9 +/- 18.5 vs. 94.5 +/- 14.4%) (p < 0.001) and FVC (92.2 +/- 15.1 vs. 95.3 +/- 12.3%) (p = 0.002). These differences remained significant after adjusting for age, BMI, CRP and smoking. Hypertension and CRP levels above the median were both independently and additively associated with lower FEV(1) and FVC. In addition a lower FVC% was also associated with a higher BMI (> 30 mg/m2). Use of betablocking antihypertensives was not related to lung function. Hypertension, BMI and systemic inflammation affect lung function independently of each other. All three variables have a negative effect on FVC, while hypertension and high CRP were independently associated with impaired FEV(1).
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Chronic airflow obstruction and markers of systemic inflammation: results from the BOLD study in Iceland.
- Authors: Thorleifsson SJ, Margretardottir OB, Gudmundsson G, Olafsson I, Benediktsdottir B, Janson C, Buist AS, Gislason T
- Issue date: 2009 Oct
- Airflow obstruction, atherosclerosis and cardiovascular risk factors in the AGES Reykjavik study.
- Authors: Gudmundsson G, Margretardottir OB, Sigurdsson MI, Harris TB, Launer LJ, Sigurdsson S, Olafsson O, Aspelund T, Gudnason V
- Issue date: 2016 Sep
- Gender differences in the association between C-reactive protein, lung function impairment, and COPD.
- Authors: Olafsdóttir IS, Gíslason T, Thjódleifsson B, Olafsson I, Gíslason D, Jõgi R, Janson C
- Issue date: 2007
- Impairment of pulmonary function is an independent risk factor for atrial fibrillation: the Takahata study.
- Authors: Shibata Y, Watanabe T, Osaka D, Abe S, Inoue S, Tokairin Y, Igarashi A, Yamauchi K, Kimura T, Kishi H, Aida Y, Nunomiya K, Nemoto T, Sato M, Konta T, Kawata S, Kato T, Kayama T, Kubota I
- Issue date: 2011
- Bronchial airflow limitation, smoking, body mass index, and statin use are strongly associated with the C-reactive protein level in the elderly. The Tromsø Study 2001.
- Authors: Melbye H, Halvorsen DS, Hartz I, Medbø A, Brox J, Eggen AE, Njølstad I
- Issue date: 2007 Dec