Electrical impedence tomography and heterogeneity of pulmonary perfusion and ventilation in porcine acute lung injury.
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CitationActa Anaesthesiol Scand. 2009, 53(10):1300-9
AbstractBACKGROUND: The heterogeneity of pulmonary ventilation (V), perfusion (Q) and V/Q matching impairs gas exchange in an acute lung injury (ALI). This study investigated the feasibility of electrical impedance tomography (EIT) to assess the V/Q distribution and matching during an endotoxinaemic ALI in pigs. METHODS: Mechanically ventilated, anaesthetised pigs (n=11, weight 30-36 kg) were studied during an infusion of endotoxin for 150 min. Impedance changes related to ventilation (Z(V)) and perfusion (Z(Q)) were monitored globally and bilaterally in four regions of interest (ROIs) of the EIT image. The distribution and ratio of Z(V) and Z(Q) were assessed. The alveolar-arterial oxygen difference, venous admixture, fractional alveolar dead space and functional residual capacity (FRC) were recorded, together with global and regional lung compliances and haemodynamic parameters. Values are mean+/-standard deviation (SD) and regression coefficients. RESULTS: Endotoxinaemia increased the heterogeneity of Z(Q) but not Z(V). Lung compliance progressively decreased with a ventral redistribution of Z(V). A concomitant dorsal redistribution of Z(Q) resulted in mismatch of global (from Z(V)/Z(Q) 1.1+/-0.1 to 0.83+/-0.3) and notably dorsal (from Z(V)/Z(Q) 0.86+/-0.4 to 0.51+/-0.3) V and Q. Changes in global Z(V)/Z(Q) correlated with changes in the alveolar-arterial oxygen difference (r(2)=0.65, P<0.05), venous admixture (r(2)=0.66, P<0.05) and fractional alveolar dead space (r(2)=0.61, P<0.05). Decreased end-expiratory Z(V) correlated with decreased FRC (r(2)=0.74, P<0.05). CONCLUSIONS: EIT can be used to assess the heterogeneity of regional pulmonary ventilation and perfusion and V/Q matching during endotoxinaemic ALI, identifying pivotal pathophysiological changes.
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- Electrical impedance tomography applied to assess matching of pulmonary ventilation and perfusion in a porcine experimental model.
- Authors: Fagerberg A, Stenqvist O, Aneman A
- Issue date: 2009
- Ventilation-perfusion distributions in different porcine lung injury models.
- Authors: Neumann P, Hedenstierna G
- Issue date: 2001 Jan
- [Ventilation-perfusion ratio in patients with acute respiratory insufficiency].
- Authors: Bein T, Reber A, Stjernström H, Metz C, Taeger K, Hedenstierna G
- Issue date: 1996 Apr
- Ventilation-perfusion inequality in patients undergoing cardiac surgery.
- Authors: Hachenberg T, Tenling A, Nyström SO, Tyden H, Hedenstierna G
- Issue date: 1994 Mar
- The effects of nitric oxide inhalation on respiratory mechanics and gas exchange during endotoxaemia in the pig.
- Authors: Dahm PL, Jonson B, De Robertis E, Myhre E, Svantesson C, Thörne J, Blomquist S
- Issue date: 1998 May