Electrical impedence tomography and heterogeneity of pulmonary perfusion and ventilation in porcine acute lung injury.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationActa Anaesthesiol Scand. 2009, 53(10):1300-9
AbstractBACKGROUND: The heterogeneity of pulmonary ventilation (V), perfusion (Q) and V/Q matching impairs gas exchange in an acute lung injury (ALI). This study investigated the feasibility of electrical impedance tomography (EIT) to assess the V/Q distribution and matching during an endotoxinaemic ALI in pigs. METHODS: Mechanically ventilated, anaesthetised pigs (n=11, weight 30-36 kg) were studied during an infusion of endotoxin for 150 min. Impedance changes related to ventilation (Z(V)) and perfusion (Z(Q)) were monitored globally and bilaterally in four regions of interest (ROIs) of the EIT image. The distribution and ratio of Z(V) and Z(Q) were assessed. The alveolar-arterial oxygen difference, venous admixture, fractional alveolar dead space and functional residual capacity (FRC) were recorded, together with global and regional lung compliances and haemodynamic parameters. Values are mean+/-standard deviation (SD) and regression coefficients. RESULTS: Endotoxinaemia increased the heterogeneity of Z(Q) but not Z(V). Lung compliance progressively decreased with a ventral redistribution of Z(V). A concomitant dorsal redistribution of Z(Q) resulted in mismatch of global (from Z(V)/Z(Q) 1.1+/-0.1 to 0.83+/-0.3) and notably dorsal (from Z(V)/Z(Q) 0.86+/-0.4 to 0.51+/-0.3) V and Q. Changes in global Z(V)/Z(Q) correlated with changes in the alveolar-arterial oxygen difference (r(2)=0.65, P<0.05), venous admixture (r(2)=0.66, P<0.05) and fractional alveolar dead space (r(2)=0.61, P<0.05). Decreased end-expiratory Z(V) correlated with decreased FRC (r(2)=0.74, P<0.05). CONCLUSIONS: EIT can be used to assess the heterogeneity of regional pulmonary ventilation and perfusion and V/Q matching during endotoxinaemic ALI, identifying pivotal pathophysiological changes.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Electrical impedance tomography applied to assess matching of pulmonary ventilation and perfusion in a porcine experimental model.
- Authors: Fagerberg A, Stenqvist O, Aneman A
- Issue date: 2009
- Capnography reflects ventilation/perfusion distribution in a model of acute lung injury.
- Authors: Tusman G, Suarez-Sipmann F, Bohm SH, Borges JB, Hedenstierna G
- Issue date: 2011 May
- Determination of respiratory gas flow by electrical impedance tomography in an animal model of mechanical ventilation.
- Authors: Bodenstein M, Boehme S, Bierschock S, Vogt A, David M, Markstaller K
- Issue date: 2014 Apr 29
- Electrical impedance tomography is able to track changes in respiratory function in endotoxin-challenged rodents.
- Authors: Herber-Jonat S, Hajek K, Mittal R, Just A, Hahn G, Schulze A, Flemmer AW
- Issue date: 2009 Jul
- Analysis of regional compliance in a porcine model of acute lung injury.
- Authors: Czaplik M, Biener I, Dembinski R, Pelosi P, Soodt T, Schroeder W, Leonhardt S, Marx G, Rossaint R, Bickenbach J
- Issue date: 2012 Oct 15