The effects of IL-6 on cell adhesion and e-cadherin expression in breast cancer.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationCytokine. 1998, 10(9):720-8
AbstractInterleukin 6 (IL-6) is a pleiotropic inflammatory cytokine and its role in cancer is not yet clear. The effects of IL-6 on four breast cancer cell lines and normal mammary epithelium, cultured from milk were tested. Four different patterns of response to IL-6 were found depending on the differentiation status of the cells. In normal mammary epithelial cultures, the effects of IL-6 were mainly growth inhibitory, whereas in MCF-7, IL-6 had growth inhibitory and anti-adhesive effects. In T-47D and ZR-75-1 the anti-adhesive effects were prominent although the growth inhibitory effects were not. These anti-adhesive effects were associated with epithelioid to fibroblastoid morphological changes and a local decrease in E-cadherin expression. In the highly invasive cell line MDA-MB-231, which does not express E-cadherin, no effects of IL-6 were seen. IL-6 levels in the serum of 60 breast cancer patients were found to be increased in 27% (16/60) compared to 2% (1/50) in a control group. Furthermore, it was found that altered E-cadherin expression was seen in 69% of the primary tumours, although no significant association was found between raised serum IL-6 levels and altered E-cadherin expression. Finally IL-6 serum levels did not effect the survival of breast cancer patients. The authors therefore implicate IL-6 as a possible factor important in breast cancer progression and metastasis formation, although the clinical significance of this cytokine in breast cancer patients could not be established.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Retinoic acid induces expression of the interleukin-1beta gene in cultured normal human mammary epithelial cells and in human breast carcinoma lines.
- Authors: Liu L, Gudas LJ
- Issue date: 2002 Nov
- Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition.
- Authors: Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H, Taya Y
- Issue date: 2008 Jul 1
- Functional characterization of E- and P-cadherin in invasive breast cancer cells.
- Authors: Sarrió D, Palacios J, Hergueta-Redondo M, Gómez-López G, Cano A, Moreno-Bueno G
- Issue date: 2009 Mar 3
- Evidences that leptin up-regulates E-cadherin expression in breast cancer: effects on tumor growth and progression.
- Authors: Mauro L, Catalano S, Bossi G, Pellegrino M, Barone I, Morales S, Giordano C, Bartella V, Casaburi I, Andò S
- Issue date: 2007 Apr 1
- Overexpression of macrophage migration inhibitory factor induces angiogenesis in human breast cancer.
- Authors: Xu X, Wang B, Ye C, Yao C, Lin Y, Huang X, Zhang Y, Wang S
- Issue date: 2008 Mar 18