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Authors
Trausti ÓskarssonÓlafur Gísli Jónsson
Jón R. Kristinsson
Guðmundur K. Jónmundsson
Jón Gunnlaugur Jónasson
Ásgeir Haraldsson
Issue Date
2010-01-01
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Childhood cancer in Iceland 1981-2006Citation
Læknablaðið 2010, 96(1):21-6Abstract
BACKGROUND: Childhood cancer is the second most common cause of death in children. The aim of this study was to gather epidemiological information on childhood cancer in Iceland. METHODS: The study was population based and included all children younger than 18 years of age, diagnosed with cancer in Iceland from 1981 to 2006. Information was extracted from the Icelandic Cancer Registry and patient hospital records. RESULTS: During the study period 288 cancer cases were diagnosed in 279 children, 10 cases were secondary neoplasms. Age standardized incidence was 16.1 per 100.000 (95% CI 13,6-18,6) for boys and 12.8 per 100.000 (95% CI 10,5-15,0) for girls. There was no significant difference in the incidence rate between the first and second half of the study period. For children aged 0-14 years, the age standardized incidence was 13.6 per 100.000. The incidence was highest in the 0-4 year age group (17.3 per 100.000) and in the 15-17 year age group (19.6 per 100.000). Brain tumors (27.1%) and leukemia (25.0%) were the most common cancer groups diagnosed. Lymphoid leukemia was the most common cancer type (17.9%) and astrocytoma (13.1%) came second. CONCLUSIONS: The incidence of childhood cancer in Iceland is similar to other Western countries. Long-term follow-up is very important in childhood cancer survivors.Inngangur: Krabbamein er næst algengasta dánarorsök barna á eftir slysum. Tilgangur rann-sóknarinnar var að kanna nýgengi krabbameina hjá börnum á Íslandi. Aðferðir: Rannsóknin var lýðgrunduð og náði til allra <18 ára sem greindust með krabbamein á Íslandi frá upphafi árs 1981 til ársloka 2006. Upplýsingum var safnað frá Krabbameinsskrá Íslands og úr sjúkraskrám. Niðurstöður: Alls greindust 288 krabbameinstilfelli á tímabilinu hjá 279 börnum. Í 10 tilvikum var um meðferðartengd krabbamein að ræða. Árlegt aldursstaðlað nýgengi hjá drengjum var 16,1 af 100.000 (95% CI; 13,6-18,6) en hjá stúlkum 12,8 af 100.000 (95% CI; 10,5-15,0) en ekki var marktækur munur á nýgengi milli fyrri og seinni hluta rannsóknartímabilsins. Fyrir aldursbilið 0-14 ára var árlegt aldursstaðlað nýgengi 13,6 af 100.000. Miðtaugakerfisæxli og hvítblæði voru samanlagt 52,1% allra krabbameinstilvika. Algengasta grein-ingin var bráða eitilfrumuhvítblæði (17,9%) og stjarnfrumnaæxli (13,1%) næstalgengust. Nýgeng-ið var hæst hjá aldursbilunum 0-4 ára (17,3 af 100.00) og 15-17 ára (19,6 af 100.000). Tíu börn voru með þekkta meðfædda áhættuþætti. Ályktun: Nýgengi krabbameina hjá börnum á Íslandi er sambærilegt við nágrannalöndin. Mikilvægt er að fylgja vel eftir börnum sem gengið hafa í gegnum krabbameinsmeðferð og þeim sem hafa þekkta meðfædda áhættuþætti.
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