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The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men

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Authors
Walderhaug, Espen
Herman, Aryeh Isaac
Magnusson, Andres
Morgan, Michael John
Landrø, Nils Inge
Issue Date
2010-04-01

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Neurosci. Lett. 2010, 473(3):208-11
Abstract
Reduced serotonergic neurotransmission is implicated in impulsive behavior. We studied the triallelic system of the serotonin transporter gene linked polymorphic region (5-HTTLPR) and acute manipulation of serotonin together to further delineate the mechanisms by which serotonergic neurotransmission affects impulsivity. Fifty-two healthy participants (38 men and 14 women) underwent acute tryptophan depletion (ATD) or placebo in a randomized, double-blind, parallel group experiment. Impulsive response style was measured on two versions of the Continuous Performance Task (CPT), and calculated using signal detection theory. We observed a dose-dependent effect for the short (S') allele of the 5-HTTLPR on impulsive response style. Individuals who had the S'/S' genotype were more impulsive than individuals with the L/S' genotype. Participants with the L/S' genotype were more impulsive than those with the L/L genotype. ATD increased impulsivity in men, and decreased impulsivity in women. These data demonstrate for the first time that reduced serotonergic tone as a result of either 5-HTTLPR genotype, or experimental ATD, are both independently and additively, associated with elevated impulsive response style in Caucasian men.
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http://dx.doi.org/10.1016/j.neulet.2010.02.048
ae974a485f413a2113503eed53cd6c53
10.1016/j.neulet.2010.02.048
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