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dc.contributor.authorBjornsson, G L*
dc.contributor.authorThorsteinsson, L*
dc.contributor.authorGudmundsson, K O*
dc.contributor.authorJonsson, H*
dc.contributor.authorGudmundsson, S*
dc.contributor.authorGudbjornsson, B*
dc.date.accessioned2007-03-07T08:47:33Z
dc.date.available2007-03-07T08:47:33Z
dc.date.issued2007-01-01
dc.date.submitted2007-03-06
dc.identifier.citationScand. J. Immunol. 2007, 65(1):99-105en
dc.identifier.issn0300-9475
dc.identifier.pmid17212773
dc.identifier.doi10.1111/j.1365-3083.2006.01872.x
dc.identifier.otherBAB12
dc.identifier.otherRHE12
dc.identifier.otherORT12
dc.identifier.urihttp://hdl.handle.net/2336/9826
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOur objective was to investigate the initiation and course of pro- and anti-inflammatory cytokines in early inflammatory response and to elucidate the cytokine system in relation to the adrenal response caused by stress. Seven blood samples were collected, pre- and postoperatively (0-72 h) after total hip replacement (THR) due to osteoarthritis. The following cytokines were measured using Cytometric Bead Array: interleukin-1beta (IL-1beta), IL-6, tumour necrosis factor-alpha, IL-8, IL-12 and IL-10 (B&D). Thirteen patients took part in the study (67 +/- 9 years). C-reactive protein increased from <6 to over 200 mg/l on the second post-op day. The concentration of IL-6 increased 10-fold just 3 h post-op (4-47 pg/ml) and reached its maximum value 6 h post-op (77 pg/ml; Wilcoxon test P < 0.01) Repeated measurements were also significant (Friedman P < 0.05). The concentration of IL-8 doubled the day of surgery but did not reach a significant level (Friedman test =0.069). None of the other cytokines showed any significant changes. The diurnal cortisol rhythm was interrupted after the surgery and there was a significant correlation between the cortisol secretion and IL-6 response. This study demonstrates an isolated elevation in IL-6 levels with only a minor elevation in IL-8 following THR. This pro-inflammatory response seemed to decline without activation of anti-inflammatory cytokines (IL-10), but cortisol seemed to play a complicated role in halting the acute inflammatory response.
dc.language.isoenen
dc.publisherBlackwell Scientific Publicationsen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/full/10.1111/j.1365-3083.2006.01872.xen
dc.subject.meshAdrenal Glandsen
dc.subject.meshAged, 80 and overen
dc.subject.meshAgeden
dc.subject.meshArthroplasty, Replacement, Hipen
dc.subject.meshC-Reactive Proteinen
dc.subject.meshCytokinesen
dc.subject.meshHumansen
dc.subject.meshFemaleen
dc.subject.meshHydrocortisoneen
dc.subject.meshInterleukin-10en
dc.subject.meshInterleukin-6en
dc.subject.meshInterleukin-8en
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.titleInflammatory cytokines in relation to adrenal response following total hip replacementen
dc.typeArticleen
dc.identifier.journalScandinavian journal of immunologyen
dc.format.digYES
html.description.abstractOur objective was to investigate the initiation and course of pro- and anti-inflammatory cytokines in early inflammatory response and to elucidate the cytokine system in relation to the adrenal response caused by stress. Seven blood samples were collected, pre- and postoperatively (0-72 h) after total hip replacement (THR) due to osteoarthritis. The following cytokines were measured using Cytometric Bead Array: interleukin-1beta (IL-1beta), IL-6, tumour necrosis factor-alpha, IL-8, IL-12 and IL-10 (B&D). Thirteen patients took part in the study (67 +/- 9 years). C-reactive protein increased from <6 to over 200 mg/l on the second post-op day. The concentration of IL-6 increased 10-fold just 3 h post-op (4-47 pg/ml) and reached its maximum value 6 h post-op (77 pg/ml; Wilcoxon test P < 0.01) Repeated measurements were also significant (Friedman P < 0.05). The concentration of IL-8 doubled the day of surgery but did not reach a significant level (Friedman test =0.069). None of the other cytokines showed any significant changes. The diurnal cortisol rhythm was interrupted after the surgery and there was a significant correlation between the cortisol secretion and IL-6 response. This study demonstrates an isolated elevation in IL-6 levels with only a minor elevation in IL-8 following THR. This pro-inflammatory response seemed to decline without activation of anti-inflammatory cytokines (IL-10), but cortisol seemed to play a complicated role in halting the acute inflammatory response.


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