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dc.contributor.authorVidal, Jean-Sébastien
dc.contributor.authorSigurdsson, Sigurdur
dc.contributor.authorJonsdottir, Maria K
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorThorgeirsson, Gudmundur
dc.contributor.authorKjartansson, Olafur
dc.contributor.authorGarcia, Melissa E
dc.contributor.authorvan Buchem, Mark A
dc.contributor.authorHarris, Tamara B
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorLauner, Lenore J
dc.date.accessioned2010-05-25T14:51:47Z
dc.date.available2010-05-25T14:51:47Z
dc.date.issued2010-05-01
dc.date.submitted2010-05-25
dc.identifier.citationStroke. 2010, 41(5):891-7en
dc.identifier.issn1524-4628
dc.identifier.pmid20360538
dc.identifier.doi10.1161/STROKEAHA.110.579581
dc.identifier.urihttp://hdl.handle.net/2336/99815
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND AND PURPOSE: Several cardiovascular risk factors are associated with cognitive disorders in older persons. Little is known about the association of the burden of coronary atherosclerosis with brain structure and function. METHODS: This is a cross-sectional analysis of data from the Age, Gene, Environment Susceptibility (AGES)-Reykjavik Study cohort of men and women born 1907 to 1935. Coronary artery calcification (CAC), a marker of atherosclerotic burden, was measured with CT. Memory, speed of processing, and executive function composites were calculated from a cognitive test battery. Dementia was assessed in a multistep procedure and diagnosed according to international guidelines. Quantitative data on total intracranial and tissue volumes (total, gray matter volume, white matter volume, and white matter lesion volume), cerebral infarcts, and cerebral microbleeds were obtained with brain MRI. The association of CAC with dementia (n=165 cases) and cognitive function in nondemented subjects (n=4085), and separately with MRI outcomes, was examined in multivariate models adjusting for demographic and vascular risk factors. Analyses tested whether brain structure mediated the associations of CAC to cognitive function. RESULTS: Subjects with higher CAC were more likely to have dementia and lower cognitive scores, more likely to have lower white matter volume, gray matter volume, and total brain tissue, and to have more cerebral infarcts, cerebral microbleeds, and white matter lesions. The relations of cognitive performance and dementia to CAC were significantly attenuated when the models were adjusted for brain lesions and volumes. CONCLUSIONS: In a population-based sample, increasing atherosclerotic load assessed by CAC is associated with poorer cognitive performance and dementia, and these relations are mediated by evidence of brain pathology.
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://dx.doi.org/10.1161/STROKEAHA.110.579581en
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAgingen
dc.subject.meshBrainen
dc.subject.meshCalcinosisen
dc.subject.meshCognition Disordersen
dc.subject.meshCohort Studiesen
dc.subject.meshCoronary Artery Diseaseen
dc.subject.meshCoronary Vesselsen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshEnvironmenten
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshMaleen
dc.titleCoronary artery calcium, brain function and structure: the AGES-Reykjavik Studyen
dc.typeArticleen
dc.contributor.departmentNational Institutes of Health, NIA/LEDB, 7201 Wisconsin Ave, Gateway Building, Suite 3C309, Bethesda, MD 20892-9205, USA.en
dc.identifier.journalStroke; a journal of cerebral circulationen
html.description.abstractBACKGROUND AND PURPOSE: Several cardiovascular risk factors are associated with cognitive disorders in older persons. Little is known about the association of the burden of coronary atherosclerosis with brain structure and function. METHODS: This is a cross-sectional analysis of data from the Age, Gene, Environment Susceptibility (AGES)-Reykjavik Study cohort of men and women born 1907 to 1935. Coronary artery calcification (CAC), a marker of atherosclerotic burden, was measured with CT. Memory, speed of processing, and executive function composites were calculated from a cognitive test battery. Dementia was assessed in a multistep procedure and diagnosed according to international guidelines. Quantitative data on total intracranial and tissue volumes (total, gray matter volume, white matter volume, and white matter lesion volume), cerebral infarcts, and cerebral microbleeds were obtained with brain MRI. The association of CAC with dementia (n=165 cases) and cognitive function in nondemented subjects (n=4085), and separately with MRI outcomes, was examined in multivariate models adjusting for demographic and vascular risk factors. Analyses tested whether brain structure mediated the associations of CAC to cognitive function. RESULTS: Subjects with higher CAC were more likely to have dementia and lower cognitive scores, more likely to have lower white matter volume, gray matter volume, and total brain tissue, and to have more cerebral infarcts, cerebral microbleeds, and white matter lesions. The relations of cognitive performance and dementia to CAC were significantly attenuated when the models were adjusted for brain lesions and volumes. CONCLUSIONS: In a population-based sample, increasing atherosclerotic load assessed by CAC is associated with poorer cognitive performance and dementia, and these relations are mediated by evidence of brain pathology.


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